The effect of aminophylline administration on 99mTc-MIBI lung and liver uptake in patients with or without myocardial ischemia

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dc.authorscopusid57197111786
dc.authorscopusid6507772792
dc.authorscopusid7005722551
dc.authorscopusid35576100800
dc.contributor.authorYüksel M.
dc.contributor.authorDurmus Altun G.
dc.contributor.authorAltun A.
dc.contributor.authorBerkarda S.
dc.date.accessioned2024-06-12T10:25:08Z
dc.date.available2024-06-12T10:25:08Z
dc.date.issued2000
dc.description.abstractThis work aims to analyze the influence of aminophylline in the pulmonary and hepatic uptake of 99mTc-methoxyisobutil isonitrile ( 99mTc-MIBI). 72 patients were studied and a myocardial perfusion (MPS) single photon emission computed tomography (SPECT) with 99mTc-MIBI was carried out after the administration of dipyridamole. According to the MPS, the patients were classified into 2 groups: Group A: 45 patients without myocardial ischemia and Group B: 27 with ischemia. Each group was divided into 2 subgroups according to whether they had (I) or had not (II) received intravenous aminophylline. The dipyridamole was administered for 4 minutes at a dose of 0.56 mg/kg. If the patients presented any complication, intravenous aminophylline was administered. At 30 minutes p.i., planar images were obtained during a scintigraphy in the interior projection after the injection of 99mTc-MIBI. The regions of interest in the heart, hepatic cupula, and most active area of the left lung were outlines and the activity rates were calculated: lung/heart (LHR) and liver/heart (LivHR). No statistically significant differences were observed in the uptake of 99mTc-MIBI between subgroups I and II. However, the LHR rates in both subgroups were significantly lower in the patients with normal myocardial perfusion than in the patients with ischemia: LHR group A1 vs B1: 0.32 ± 0.08 vs 0.36 ± 0.06, p = 0.03; group AII vs BII 0.31 ± 0.07 vs 0.35 ± 0.07, p = 0.01 respectively. In conclusion, the administration of aminophylline, after the infusion of dipyridamole for MPS, does not modify the pulmonary or hepatic uptake of 99mTc-MIBI.en_US
dc.identifier.doi10.1016/S0212-6982(00)71904-5
dc.identifier.endpage427en_US
dc.identifier.issn0212-6982
dc.identifier.issue6en_US
dc.identifier.pmid11060272en_US
dc.identifier.scopus2-s2.0-0034292827en_US
dc.identifier.scopusqualityN/Aen_US
dc.identifier.startpage423en_US
dc.identifier.urihttps://doi.org/10.1016/S0212-6982(00)71904-5
dc.identifier.urihttps://hdl.handle.net/20.500.14551/16185
dc.identifier.volume19en_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherEdiciones Doyma, S.L.en_US
dc.relation.ispartofRevista Espanola de Medicina Nuclearen_US
dc.relation.publicationcategoryKonferans Öğesi - Uluslararası - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subject99mtc-Mibi; Aminophylline; Hepatic Uptake; Ischemia; Pulmonary Uptakeen_US
dc.subjectAminophylline; Dipyridamole; Methoxy Isobutyl Isonitrile Technetium Tc 99m; Aminophylline; Cardiotonic Agent; Diagnostic Agent; Methoxy Isobutyl Isonitrile Technetium Tc 99m; Radiopharmaceutical Agent; Vasodilator Agent; Adult; Aged; Conference Paper; Controlled Study; Drug Effect; Drug Uptake; Echocardiography; Electrocardiogram; Female; Heart Muscle Ischemia; Heart Muscle Perfusion; Human; Image Analysis; Liver; Lung; Major Clinical Study; Male; Scintigraphy; Single Photon Emission Computer Tomography; Analysis Of Variance; Article; Heart Muscle Ischemia; Liver; Lung; Metabolism; Middle Aged; Retrospective Study; Adult; Aged; Aminophylline; Analysis Of Variance; Cardiotonic Agents; Dipyridamole; Female; Humans; Liver; Lung; Male; Middle Aged; Myocardial Ischemia; Radiopharmaceuticals; Retrospective Studies; Technetium Tc 99m Sestamibi; Tomography, Emission-Computed, Single-Photon; Vasodilator Agentsen_US
dc.titleThe effect of aminophylline administration on 99mTc-MIBI lung and liver uptake in patients with or without myocardial ischemiaen_US
dc.typeConference Objecten_US

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