The effect of aminophylline administration on 99mTc-MIBI lung and liver uptake in patients with or without myocardial ischemia
Küçük Resim Yok
Tarih
2000
Yazarlar
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
Ediciones Doyma, S.L.
Erişim Hakkı
info:eu-repo/semantics/closedAccess
Özet
This work aims to analyze the influence of aminophylline in the pulmonary and hepatic uptake of 99mTc-methoxyisobutil isonitrile ( 99mTc-MIBI). 72 patients were studied and a myocardial perfusion (MPS) single photon emission computed tomography (SPECT) with 99mTc-MIBI was carried out after the administration of dipyridamole. According to the MPS, the patients were classified into 2 groups: Group A: 45 patients without myocardial ischemia and Group B: 27 with ischemia. Each group was divided into 2 subgroups according to whether they had (I) or had not (II) received intravenous aminophylline. The dipyridamole was administered for 4 minutes at a dose of 0.56 mg/kg. If the patients presented any complication, intravenous aminophylline was administered. At 30 minutes p.i., planar images were obtained during a scintigraphy in the interior projection after the injection of 99mTc-MIBI. The regions of interest in the heart, hepatic cupula, and most active area of the left lung were outlines and the activity rates were calculated: lung/heart (LHR) and liver/heart (LivHR). No statistically significant differences were observed in the uptake of 99mTc-MIBI between subgroups I and II. However, the LHR rates in both subgroups were significantly lower in the patients with normal myocardial perfusion than in the patients with ischemia: LHR group A1 vs B1: 0.32 ± 0.08 vs 0.36 ± 0.06, p = 0.03; group AII vs BII 0.31 ± 0.07 vs 0.35 ± 0.07, p = 0.01 respectively. In conclusion, the administration of aminophylline, after the infusion of dipyridamole for MPS, does not modify the pulmonary or hepatic uptake of 99mTc-MIBI.
Açıklama
Anahtar Kelimeler
99mtc-Mibi; Aminophylline; Hepatic Uptake; Ischemia; Pulmonary Uptake, Aminophylline; Dipyridamole; Methoxy Isobutyl Isonitrile Technetium Tc 99m; Aminophylline; Cardiotonic Agent; Diagnostic Agent; Methoxy Isobutyl Isonitrile Technetium Tc 99m; Radiopharmaceutical Agent; Vasodilator Agent; Adult; Aged; Conference Paper; Controlled Study; Drug Effect; Drug Uptake; Echocardiography; Electrocardiogram; Female; Heart Muscle Ischemia; Heart Muscle Perfusion; Human; Image Analysis; Liver; Lung; Major Clinical Study; Male; Scintigraphy; Single Photon Emission Computer Tomography; Analysis Of Variance; Article; Heart Muscle Ischemia; Liver; Lung; Metabolism; Middle Aged; Retrospective Study; Adult; Aged; Aminophylline; Analysis Of Variance; Cardiotonic Agents; Dipyridamole; Female; Humans; Liver; Lung; Male; Middle Aged; Myocardial Ischemia; Radiopharmaceuticals; Retrospective Studies; Technetium Tc 99m Sestamibi; Tomography, Emission-Computed, Single-Photon; Vasodilator Agents
Kaynak
Revista Espanola de Medicina Nuclear
WoS Q Değeri
Scopus Q Değeri
N/A
Cilt
19
Sayı
6
