The modifying effect of ibuprofen on total body irradiation-induced elevation of oxidative reactions in male hamsters

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dc.authorscopusid6602917963
dc.authorscopusid6506066874
dc.authorscopusid6602427108
dc.authorscopusid6507030833
dc.authorscopusid8560325700
dc.contributor.authorDokmeci D.
dc.contributor.authorAkpolat M.
dc.contributor.authorAydogdu N.
dc.contributor.authorUzal C.
dc.contributor.authorTuran N.F.
dc.date.accessioned2024-06-12T10:28:10Z
dc.date.available2024-06-12T10:28:10Z
dc.date.issued2004
dc.description.abstractRadiation therapy plays an important role in curative and palliative treatments of malignant diseases. Because of the lipid component in the membrane, lipid peroxidation has been reported to be particularly susceptible to radiation damage. However, lipid peroxidation is reversed by cellular defense mechanisms, and the use of various antioxidants involved in these mechanisms have recently been suggested to be beneficial. It is known that ibuprofen has antioxidative and/or free radical scavenging activities. Our purpose is to examine the antioxidant capacity of ibuprofen in hamsters undergoing total body irradiation (TBI). Ibuprofen was given by gavage at dose of 10 mg/kg for 15 consecutive days. After this period, animals were exposed to TBI 60Co gamma irradiation with a single dose of 8 Gy. After 24 h radiation exposure, the hamsters were killed and samples were taken from blood. Plasma thiobarbituric acid reactive substances (TBARS) increased significantly after radiation exposure, and ibuprofen diminished the amounts of TBARS. Significant protection of the radiation-induced changes in the activities of superoxide dismutase (SOD) and catalase was also recorded in the blood of ibuprofen-treated and -irradiated hamsters. These results suggest that ibuprofen with its antioxidant capacity could play a modulatory role against cellular damage effected by free radicals induced by TBI.en_US
dc.identifier.endpage72en_US
dc.identifier.issn0567-7734
dc.identifier.issue2en_US
dc.identifier.scopus2-s2.0-4243155235en_US
dc.identifier.scopusqualityN/Aen_US
dc.identifier.startpage67en_US
dc.identifier.urihttps://hdl.handle.net/20.500.14551/17109
dc.identifier.volume52en_US
dc.indekslendigikaynakScopusen_US
dc.language.isoenen_US
dc.relation.ispartofActa Medica et Biologicaen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectCatalase; Ibuprofen; Lipid Peroxidation; Oxidative Injury; Superoxide Dismutase; Total Body Irradiationen_US
dc.subjectCatalase; Cobalt 60; Ibuprofen; Malonaldehyde; Nonsteroid Antiinflammatory Agent; Superoxide Dismutase; Thiobarbituric Acid Reactive Substance; Animal Experiment; Antioxidant Activity; Article; Cobalt Teletherapy; Controlled Study; Dosimeter; Drug Effect; Drug Mechanism; Enzyme Activity; Hamster; Ionization Chamber; Irradiation; Lipid Peroxidation; Male; Nonhuman; Radiation Dose; Whole Body Radiation; Animalia; Cricetinaeen_US
dc.titleThe modifying effect of ibuprofen on total body irradiation-induced elevation of oxidative reactions in male hamstersen_US
dc.typeArticleen_US

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