The modifying effect of ibuprofen on total body irradiation-induced elevation of oxidative reactions in male hamsters
Küçük Resim Yok
Tarih
2004
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Yayıncı
Erişim Hakkı
info:eu-repo/semantics/closedAccess
Özet
Radiation therapy plays an important role in curative and palliative treatments of malignant diseases. Because of the lipid component in the membrane, lipid peroxidation has been reported to be particularly susceptible to radiation damage. However, lipid peroxidation is reversed by cellular defense mechanisms, and the use of various antioxidants involved in these mechanisms have recently been suggested to be beneficial. It is known that ibuprofen has antioxidative and/or free radical scavenging activities. Our purpose is to examine the antioxidant capacity of ibuprofen in hamsters undergoing total body irradiation (TBI). Ibuprofen was given by gavage at dose of 10 mg/kg for 15 consecutive days. After this period, animals were exposed to TBI 60Co gamma irradiation with a single dose of 8 Gy. After 24 h radiation exposure, the hamsters were killed and samples were taken from blood. Plasma thiobarbituric acid reactive substances (TBARS) increased significantly after radiation exposure, and ibuprofen diminished the amounts of TBARS. Significant protection of the radiation-induced changes in the activities of superoxide dismutase (SOD) and catalase was also recorded in the blood of ibuprofen-treated and -irradiated hamsters. These results suggest that ibuprofen with its antioxidant capacity could play a modulatory role against cellular damage effected by free radicals induced by TBI.
Açıklama
Anahtar Kelimeler
Catalase; Ibuprofen; Lipid Peroxidation; Oxidative Injury; Superoxide Dismutase; Total Body Irradiation, Catalase; Cobalt 60; Ibuprofen; Malonaldehyde; Nonsteroid Antiinflammatory Agent; Superoxide Dismutase; Thiobarbituric Acid Reactive Substance; Animal Experiment; Antioxidant Activity; Article; Cobalt Teletherapy; Controlled Study; Dosimeter; Drug Effect; Drug Mechanism; Enzyme Activity; Hamster; Ionization Chamber; Irradiation; Lipid Peroxidation; Male; Nonhuman; Radiation Dose; Whole Body Radiation; Animalia; Cricetinae
Kaynak
Acta Medica et Biologica
WoS Q Değeri
Scopus Q Değeri
N/A
Cilt
52
Sayı
2
