Thermodynamic stability of ibuprofen loaded poloxamer micelles

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dc.authoridKacar, Gokhan/0000-0003-0359-3211
dc.authorwosidKAÇAR, Gökhan/Q-5128-2019
dc.contributor.authorKacar, Gokhan
dc.date.accessioned2024-06-12T11:16:15Z
dc.date.available2024-06-12T11:16:15Z
dc.date.issued2020
dc.departmentTrakya Üniversitesien_US
dc.description.abstractThermodynamic stability of poloxamer micelles excluding and encapsulating ibuprofen drug at different concentrations is studied by means of free energies. Free energies are computed by a partitioning of the total free energy in order to consider the different parts of the co-polymers together with free co-polymer chains in solvent. Moreover, extra terms to the free energy are added to account for the drug-micelle and drug-solvent interactions. The thermodynamic stability of the system is found to be positively correlated with the drug loading for the same system. The RDFs computed between water and the drug molecules signify the decreasing neighboring between these pairs as the co-polymer and drug concentrations are increased in the mixtures as the system leans towards a higher thermodynamic stability. In this work, not only the thermodynamic stability but also its relation to the structure are discussed for a drug-laden system demonstrating the utility of the proposed procedure.en_US
dc.description.sponsorshipTUBITAK [116C003]; Trakya University Research Fund [2017/81]en_US
dc.description.sponsorshipThe author acknowledges the financial support from TUBITAK (grant no. 116C003) and Trakya University Research Fund (project no. 2017/81).en_US
dc.identifier.doi10.1016/j.chemphys.2020.110713
dc.identifier.issn0301-0104
dc.identifier.issn1873-4421
dc.identifier.scopus2-s2.0-85079210335en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.urihttps://doi.org/10.1016/j.chemphys.2020.110713
dc.identifier.urihttps://hdl.handle.net/20.500.14551/24251
dc.identifier.volume533en_US
dc.identifier.wosWOS:000522668200015en_US
dc.identifier.wosqualityQ2en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.language.isoenen_US
dc.publisherElsevieren_US
dc.relation.ispartofChemical Physicsen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectThermodynamic Stabilityen_US
dc.subjectPolymersen_US
dc.subjectDrug Deliveryen_US
dc.subjectPoloxamersen_US
dc.subjectIbuprofenen_US
dc.subjectPolymeric Micellesen_US
dc.subjectDiblock Copolymersen_US
dc.subjectBlock-Copolymersen_US
dc.subjectDrugen_US
dc.subjectMicellizationen_US
dc.subjectDeliveryen_US
dc.subjectPoly(L-Lysine)en_US
dc.subjectSystemsen_US
dc.titleThermodynamic stability of ibuprofen loaded poloxamer micellesen_US
dc.typeArticleen_US

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