Thermodynamic stability of ibuprofen loaded poloxamer micelles
Küçük Resim Yok
Tarih
2020
Yazarlar
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
Elsevier
Erişim Hakkı
info:eu-repo/semantics/closedAccess
Özet
Thermodynamic stability of poloxamer micelles excluding and encapsulating ibuprofen drug at different concentrations is studied by means of free energies. Free energies are computed by a partitioning of the total free energy in order to consider the different parts of the co-polymers together with free co-polymer chains in solvent. Moreover, extra terms to the free energy are added to account for the drug-micelle and drug-solvent interactions. The thermodynamic stability of the system is found to be positively correlated with the drug loading for the same system. The RDFs computed between water and the drug molecules signify the decreasing neighboring between these pairs as the co-polymer and drug concentrations are increased in the mixtures as the system leans towards a higher thermodynamic stability. In this work, not only the thermodynamic stability but also its relation to the structure are discussed for a drug-laden system demonstrating the utility of the proposed procedure.
Açıklama
Anahtar Kelimeler
Thermodynamic Stability, Polymers, Drug Delivery, Poloxamers, Ibuprofen, Polymeric Micelles, Diblock Copolymers, Block-Copolymers, Drug, Micellization, Delivery, Poly(L-Lysine), Systems
Kaynak
Chemical Physics
WoS Q Değeri
Q2
Scopus Q Değeri
Q2
Cilt
533
