Relationship Between an Osteoprotegerin Gene Polymorphism and Diabetic Vascular Complications

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dc.authoridYukcu, Fulya/0000-0003-3468-2655
dc.authoridHuseyin, Serhat/0000-0003-4118-040X
dc.authorwosidYukcu, Fulya/JUL-4219-2023
dc.contributor.authorSoysal-Atile, Neslihan
dc.contributor.authorGuldiken, Sibel
dc.contributor.authorSipahi, Tammam
dc.contributor.authorYukcu, Fulya
dc.contributor.authorEkiz-Bilir, Betul
dc.contributor.authorHuseyin, Serhat
dc.contributor.authorEge, Turan
dc.date.accessioned2024-06-12T11:11:47Z
dc.date.available2024-06-12T11:11:47Z
dc.date.issued2015
dc.departmentTrakya Üniversitesien_US
dc.description.abstractBackground: Osteoprotegerin (OPG), which was recently identified as a vascular marker, is increased in patients with diabetes mellitus (DM). This study evaluated the frequency of the OPG gene single nucleotide A163G polymorphism and its association with diabetic microvascular and macrovascular complications. Methods: The A163G polymorphism of the OPG gene was assessed in the peripheral blood of 116 patients with type 2 DM and 107 healthy subjects by polymerase chain reaction and restriction fragment length polymorphism. Microvascular and macrovascular complications were evaluated in diabetic patients. Results: Statistical analysis showed no significant difference in distribution of the OPG A163G polymorphism in the diabetic and control groups. Similarly, this polymorphism was not associated with microvascular or macrovascular complications. Conclusions: This OPG polymorphism does not play a role in the development of microvascular and macrovascular complications in patients with DM.en_US
dc.identifier.doi10.7754/Clin.Lab.2014.141126
dc.identifier.endpage601en_US
dc.identifier.issn1433-6510
dc.identifier.issue5-6en_US
dc.identifier.pmid26118194en_US
dc.identifier.scopus2-s2.0-84934325152en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.startpage595en_US
dc.identifier.urihttps://doi.org/10.7754/Clin.Lab.2014.141126
dc.identifier.urihttps://hdl.handle.net/20.500.14551/22932
dc.identifier.volume61en_US
dc.identifier.wosWOS:000355782000021en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherClin Lab Publen_US
dc.relation.ispartofClinical Laboratoryen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectOsteoprotegerinen_US
dc.subjectPolymorphismen_US
dc.subjectDiabetes Mellitusen_US
dc.subjectComplicationsen_US
dc.subjectCoronary-Artery-Diseaseen_US
dc.subjectSingle Nucleotide Polymorphismen_US
dc.subjectIntima-Media Thicknessen_US
dc.subjectKappa-B Liganden_US
dc.subjectSerum Osteoprotegerinen_US
dc.subjectPromoter Regionen_US
dc.subjectPlasma Osteoprotegerinen_US
dc.subjectReceptor Activatoren_US
dc.subjectAssociationen_US
dc.subjectCalcificationen_US
dc.titleRelationship Between an Osteoprotegerin Gene Polymorphism and Diabetic Vascular Complicationsen_US
dc.typeArticleen_US

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