Relationship Between an Osteoprotegerin Gene Polymorphism and Diabetic Vascular Complications
Küçük Resim Yok
Tarih
2015
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
Clin Lab Publ
Erişim Hakkı
info:eu-repo/semantics/closedAccess
Özet
Background: Osteoprotegerin (OPG), which was recently identified as a vascular marker, is increased in patients with diabetes mellitus (DM). This study evaluated the frequency of the OPG gene single nucleotide A163G polymorphism and its association with diabetic microvascular and macrovascular complications. Methods: The A163G polymorphism of the OPG gene was assessed in the peripheral blood of 116 patients with type 2 DM and 107 healthy subjects by polymerase chain reaction and restriction fragment length polymorphism. Microvascular and macrovascular complications were evaluated in diabetic patients. Results: Statistical analysis showed no significant difference in distribution of the OPG A163G polymorphism in the diabetic and control groups. Similarly, this polymorphism was not associated with microvascular or macrovascular complications. Conclusions: This OPG polymorphism does not play a role in the development of microvascular and macrovascular complications in patients with DM.
Açıklama
Anahtar Kelimeler
Osteoprotegerin, Polymorphism, Diabetes Mellitus, Complications, Coronary-Artery-Disease, Single Nucleotide Polymorphism, Intima-Media Thickness, Kappa-B Ligand, Serum Osteoprotegerin, Promoter Region, Plasma Osteoprotegerin, Receptor Activator, Association, Calcification
Kaynak
Clinical Laboratory
WoS Q Değeri
Q4
Scopus Q Değeri
Q3
Cilt
61
Sayı
5-6
