Moistening of misoprostol tablets with acetic acid prior to vaginal administration for mid-trimester termination of anomalous pregnancy: A randomised comparison of three regimens

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dc.authorwosidYilmaz, Bulent/GPK-8613-2022
dc.authorwosidYilmaz, Bulent/HKE-5048-2023
dc.contributor.authorYilmaz, Bulent
dc.contributor.authorErtas, Ibrahim Egemen
dc.contributor.authorKelekci, Sefa
dc.contributor.authorSut, Necdet
dc.contributor.authorMollamahmutoglu, Leyla
dc.contributor.authorDanisman, Nuri
dc.date.accessioned2024-06-12T11:17:29Z
dc.date.available2024-06-12T11:17:29Z
dc.date.issued2010
dc.departmentTrakya Üniversitesien_US
dc.description.abstractMethods A total of 118 women requiring second-trimester pregnancy termination were randomly assigned to one of three treatment groups: 400 mu g 3-hourly in group A (n = 39), 600 mu g 6-hourly in group B (n = 39), and 800 mu g 12-hourly in group C (n = 40). Misoprostol tablets moistened with 3 ml of 5% acetic acid were placed into the posterior vaginal fornix. Results The median induction-abortion times in groups A (8 h [range: 3-64]) and B (9 h [4-81]) were significantly shorter (p < 0.01 and p < 0.05, respectively) than in group C (12.5 [3-72]). Moreover, expulsion rates within 24 hours in groups A (92.3%) and B (92.3%) were significantly higher (p < 0.05 in both cases) than that of group C (75%). Expulsion rate within 48 hours, number of tablets used, number of patients with retained placenta and side effects did not differ between groups. Conclusions Misoprostol moistened with acetic acid is effective for second-trimester pregnancy termination when given vaginally 3-hourly, 6-hourly or 12-hourly. The former two regimens are significantly more effective than the latter.en_US
dc.identifier.doi10.3109/13625180903417486
dc.identifier.endpage59en_US
dc.identifier.issn1362-5187
dc.identifier.issn1473-0782
dc.identifier.issue1en_US
dc.identifier.pmid20063994en_US
dc.identifier.scopus2-s2.0-77249087629en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage54en_US
dc.identifier.urihttps://doi.org/10.3109/13625180903417486
dc.identifier.urihttps://hdl.handle.net/20.500.14551/24723
dc.identifier.volume15en_US
dc.identifier.wosWOS:000274856300009en_US
dc.identifier.wosqualityQ2en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherTaylor & Francis Ltden_US
dc.relation.ispartofEuropean Journal Of Contraception And Reproductive Health Careen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subject2nd Trimester Pregnancyen_US
dc.subjectIntravaginal Misoprostolen_US
dc.subjectMedical Abortionen_US
dc.subjectMifepristoneen_US
dc.subjectSalineen_US
dc.subjectTrialen_US
dc.titleMoistening of misoprostol tablets with acetic acid prior to vaginal administration for mid-trimester termination of anomalous pregnancy: A randomised comparison of three regimensen_US
dc.typeArticleen_US

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