The effect of subthreshold depressive symptoms on cognitive functions and peripheral biomarkers in bipolar disorder

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dc.authoridSogut, Kubra/0000-0002-7275-4800
dc.authoridPALABIYIK, Orkide/0000-0002-3488-3740
dc.authoridGorgulu, Yasemin/0000-0002-3401-4879
dc.authorwosidGorgulu, Yasemin/S-4355-2017
dc.contributor.authorSogut, Kubra
dc.contributor.authorGorgulu, Yasemin
dc.contributor.authorPalabiyik, Orkide
dc.date.accessioned2024-06-12T10:54:42Z
dc.date.available2024-06-12T10:54:42Z
dc.date.issued2023
dc.departmentTrakya Üniversitesien_US
dc.description.abstractObjective: A global approach to factors responsible for functional impairment in patients with BD is necessary.Method: Ninety-three euthymic patients with BD [49 patients with SD (subthreshold depression) and 44 patients without SD] and 48 healthy controls were invited for evaluation of demographic, clinical, and cognitive characteristics. To define SD, the lower limit was HDRS =4 points and the upper limit was HDRS <9 points. Stroop test, California verbal learning test, digit-span test, controlled word association test, and clock drawing test were performed. Serum BDNF levels were measured. Additionally in the BD group; blood drug (lithium, valproic acid), leukocyte, C-reactive protein (CRP), TSH, and vitamin B12 levels were measured.Results: We found no difference between serum BDNF levels of BD (n = 93) and controls. The cognitive performances of the BD group were worse than the control group (p < 0.001). Attention, working memory, and stroop performance of patients with SD were worse than patients without SD (p < 0.05). Verbal fluency, stroop test, and planning performance decreased as serum CRP level increased in patients with BD (p < 0.05).Conclusions: Although the patient group with SD was in euthymia, their cognitive performance was worse than the group without SD. Poor cognitive performance in BD was associated with serum CRP levels.en_US
dc.description.sponsorshipWe thank Professor Sut Necdet (Trakya University, School of Medicine, Department of Biostatistics) for the statistical analysis of our study.en_US
dc.description.sponsorshipWe thank Professor Sut Necdet (Trakya University, School of Medicine, Department of Biostatistics) for the statistical analysis of our study.en_US
dc.identifier.doi10.1080/08039488.2023.2251448
dc.identifier.endpage777en_US
dc.identifier.issn0803-9488
dc.identifier.issn1502-4725
dc.identifier.issue8en_US
dc.identifier.pmid37668000en_US
dc.identifier.scopus2-s2.0-85169798414en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage768en_US
dc.identifier.urihttps://doi.org/10.1080/08039488.2023.2251448
dc.identifier.urihttps://hdl.handle.net/20.500.14551/19154
dc.identifier.volume77en_US
dc.identifier.wosWOS:001061987900001en_US
dc.identifier.wosqualityN/Aen_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherTaylor & Francis Ltden_US
dc.relation.ispartofNordic Journal Of Psychiatryen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectBipolar Disorderen_US
dc.subjectDepressionen_US
dc.subjectCognitionen_US
dc.subjectBDNFen_US
dc.subjectC-Reactive Proteinen_US
dc.subjectC-Reactive Proteinen_US
dc.subjectNeurotrophic Factoren_US
dc.subjectNeurocognitive Functionen_US
dc.subjectResidual Symptomsen_US
dc.subjectEuthymic Patientsen_US
dc.subjectSerum-Levelsen_US
dc.subjectBrainen_US
dc.subjectBdnfen_US
dc.subjectPerformanceen_US
dc.subjectPostmortemen_US
dc.titleThe effect of subthreshold depressive symptoms on cognitive functions and peripheral biomarkers in bipolar disorderen_US
dc.typeArticleen_US

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