The effect of subthreshold depressive symptoms on cognitive functions and peripheral biomarkers in bipolar disorder
Küçük Resim Yok
Tarih
2023
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
Taylor & Francis Ltd
Erişim Hakkı
info:eu-repo/semantics/closedAccess
Özet
Objective: A global approach to factors responsible for functional impairment in patients with BD is necessary.Method: Ninety-three euthymic patients with BD [49 patients with SD (subthreshold depression) and 44 patients without SD] and 48 healthy controls were invited for evaluation of demographic, clinical, and cognitive characteristics. To define SD, the lower limit was HDRS =4 points and the upper limit was HDRS <9 points. Stroop test, California verbal learning test, digit-span test, controlled word association test, and clock drawing test were performed. Serum BDNF levels were measured. Additionally in the BD group; blood drug (lithium, valproic acid), leukocyte, C-reactive protein (CRP), TSH, and vitamin B12 levels were measured.Results: We found no difference between serum BDNF levels of BD (n = 93) and controls. The cognitive performances of the BD group were worse than the control group (p < 0.001). Attention, working memory, and stroop performance of patients with SD were worse than patients without SD (p < 0.05). Verbal fluency, stroop test, and planning performance decreased as serum CRP level increased in patients with BD (p < 0.05).Conclusions: Although the patient group with SD was in euthymia, their cognitive performance was worse than the group without SD. Poor cognitive performance in BD was associated with serum CRP levels.
Açıklama
Anahtar Kelimeler
Bipolar Disorder, Depression, Cognition, BDNF, C-Reactive Protein, C-Reactive Protein, Neurotrophic Factor, Neurocognitive Function, Residual Symptoms, Euthymic Patients, Serum-Levels, Brain, Bdnf, Performance, Postmortem
Kaynak
Nordic Journal Of Psychiatry
WoS Q Değeri
N/A
Scopus Q Değeri
Q2
Cilt
77
Sayı
8
