The Role of H1- and H2-Receptors in the Effect of Compound 48/80 in the Asphyxiation and Body Temperature of Mice

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dc.authorscopusid6603935299
dc.authorscopusid6603653874
dc.authorscopusid6602917963
dc.authorscopusid6603559061
dc.contributor.authorUlugöl A.
dc.contributor.authorKaradag H.
dc.contributor.authorDökmeci D.
dc.contributor.authorDökmeci I.
dc.date.accessioned2024-06-12T10:25:59Z
dc.date.available2024-06-12T10:25:59Z
dc.date.issued1996
dc.description.abstractContribution of histamine H1- and H2-receptors to the effect of compound 48/80, a potent histamine releaser, upon asphyxiation and body temperature in mice was investigated in the present experiments. Compound 48/80 showed an apparent protective potency against hypoxia and significantly prolonged the latencies for convulsions and death in a dose-dependent manner. Compound 48/80 also decreased the body temperature, which was in relation with the antihypoxic effect. Both the H1-receptor antagonist, dimethindene, and the H2-receptor antagonist, ranitidine, attenuated the hypothermic effect of compound 48/80, indicating the involvement of central histamine through both the H1- and H2-receptors. Ranitidine had no effect on the protective effect of compound 48/80 against hypoxia-induced lethality, whereas dimethindene completely antagonized it. These results suggest that the protective effect of compound 48/80 against hypoxia is mediated through histamine H1-receptors and is not related to its ability to induce hypothermia.en_US
dc.identifier.doi10.3349/ymj.1996.37.2.97
dc.identifier.endpage103en_US
dc.identifier.issn0513-5796
dc.identifier.issue2en_US
dc.identifier.pmid8711940en_US
dc.identifier.scopus2-s2.0-0030038691en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage97en_US
dc.identifier.urihttps://doi.org/10.3349/ymj.1996.37.2.97
dc.identifier.urihttps://hdl.handle.net/20.500.14551/16618
dc.identifier.volume37en_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherYonsei University College of Medicineen_US
dc.relation.ispartofYonsei Medical Journalen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectBody Temperature; Compound 48/80; Histamine; Histamine Receptors; Hypoxiaen_US
dc.subjectCompound 48-80; Dimetindene; Histamine H1 Receptor; Histamine H2 Receptor; Histamine Receptor; Ranitidine; Animal Experiment; Article; Body Temperature; Controlled Study; Convulsion; Drug Effect; Hypothermia; Hypoxia; Intraperitoneal Drug Administration; Male; Mouse; Nonhuman; Animals; Anoxia; Body Temperature; Male; Mice; Mice, Inbred Balb C; P-Methoxy-N-Methylphenethylamine; Receptors, Histamine H1; Receptors, Histamine H2; Seizuresen_US
dc.titleThe Role of H1- and H2-Receptors in the Effect of Compound 48/80 in the Asphyxiation and Body Temperature of Miceen_US
dc.typeArticleen_US

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