The Role of H1- and H2-Receptors in the Effect of Compound 48/80 in the Asphyxiation and Body Temperature of Mice
Küçük Resim Yok
Tarih
1996
Yazarlar
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
Yonsei University College of Medicine
Erişim Hakkı
info:eu-repo/semantics/closedAccess
Özet
Contribution of histamine H1- and H2-receptors to the effect of compound 48/80, a potent histamine releaser, upon asphyxiation and body temperature in mice was investigated in the present experiments. Compound 48/80 showed an apparent protective potency against hypoxia and significantly prolonged the latencies for convulsions and death in a dose-dependent manner. Compound 48/80 also decreased the body temperature, which was in relation with the antihypoxic effect. Both the H1-receptor antagonist, dimethindene, and the H2-receptor antagonist, ranitidine, attenuated the hypothermic effect of compound 48/80, indicating the involvement of central histamine through both the H1- and H2-receptors. Ranitidine had no effect on the protective effect of compound 48/80 against hypoxia-induced lethality, whereas dimethindene completely antagonized it. These results suggest that the protective effect of compound 48/80 against hypoxia is mediated through histamine H1-receptors and is not related to its ability to induce hypothermia.
Açıklama
Anahtar Kelimeler
Body Temperature; Compound 48/80; Histamine; Histamine Receptors; Hypoxia, Compound 48-80; Dimetindene; Histamine H1 Receptor; Histamine H2 Receptor; Histamine Receptor; Ranitidine; Animal Experiment; Article; Body Temperature; Controlled Study; Convulsion; Drug Effect; Hypothermia; Hypoxia; Intraperitoneal Drug Administration; Male; Mouse; Nonhuman; Animals; Anoxia; Body Temperature; Male; Mice; Mice, Inbred Balb C; P-Methoxy-N-Methylphenethylamine; Receptors, Histamine H1; Receptors, Histamine H2; Seizures
Kaynak
Yonsei Medical Journal
WoS Q Değeri
Scopus Q Değeri
Q2
Cilt
37
Sayı
2
