The role of histamine H-1-receptors in the anticonvulsive effect of morphine against maximal electroconvulsive shock in mice

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dc.authoridUlugol, Ahmet/0000-0003-4643-1124
dc.authoridKaradag, Cetin Hakan/0000-0002-4763-986X
dc.authorwosidUlugol, Ahmet/V-9665-2019
dc.authorwosidKaradag, Cetin Hakan/H-4899-2013
dc.contributor.authorKaradag, CH
dc.contributor.authorUlugol, A
dc.contributor.authorDokmeci, D
dc.contributor.authorDokmeci, I
dc.date.accessioned2024-06-12T11:08:43Z
dc.date.available2024-06-12T11:08:43Z
dc.date.issued1996
dc.departmentTrakya Üniversitesien_US
dc.description.abstractMorphine is known to release histamine from mast cells. It is also known that histamine receptors mediate some of morphine's effects on the central nervous system. The contribution of H-1- and H-2-receptors to the effect of morphine on maximal electroconvulsive shock in mice was investigated in the present experiments. Morphine showed a dose-dependent anticonvulsive effect, but produced spontaneous clonic convulsions at higher doses (100 mg/kg, i.p.). The anticonvulsive effect of morphine (1 mg/kg, i.p.) was antagonized by histamine Hi-receptor antagonists, dimethindene (0.1 mg/kg, i.p.), promethazine (0.4 mg/kg, i.p.) and pheniramine (30 mg/kg, i.p.), and naloxone (10 mg/kg, i.p.), but not by the H-2-receptor antagonist ranitidine (10-50 mu g, i.c.v.). These results show that morphine has an anticonvulsive effect via histamine H-1-receptors against maximal electroconvulsive shock in mice.en_US
dc.identifier.doi10.1254/jjp.71.109
dc.identifier.endpage112en_US
dc.identifier.issn0021-5198
dc.identifier.issue2en_US
dc.identifier.pmid8835636en_US
dc.identifier.scopus2-s2.0-0029661733en_US
dc.identifier.scopusqualityN/Aen_US
dc.identifier.startpage109en_US
dc.identifier.urihttps://doi.org/10.1254/jjp.71.109
dc.identifier.urihttps://hdl.handle.net/20.500.14551/22540
dc.identifier.volume71en_US
dc.identifier.wosWOS:A1996UT29000003en_US
dc.identifier.wosqualityN/Aen_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherJapanese Pharmacological Socen_US
dc.relation.ispartofJapanese Journal Of Pharmacologyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectMorphineen_US
dc.subjectAnticonvulsive Effecten_US
dc.subjectHistamineen_US
dc.subjectHistamine H-1-Receptoren_US
dc.subjectMaximal Electroconvulsive Shocken_US
dc.subjectCentral Nervous-Systemen_US
dc.subjectMast-Cellsen_US
dc.subjectBrain Histamineen_US
dc.subjectMouse-Brainen_US
dc.subjectRaten_US
dc.subjectTransmitteren_US
dc.subjectInvolvementen_US
dc.subjectReceptorsen_US
dc.subjectTurnoveren_US
dc.subjectReleaseen_US
dc.titleThe role of histamine H-1-receptors in the anticonvulsive effect of morphine against maximal electroconvulsive shock in miceen_US
dc.typeArticleen_US

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