The role of histamine H-1-receptors in the anticonvulsive effect of morphine against maximal electroconvulsive shock in mice
Küçük Resim Yok
Tarih
1996
Yazarlar
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
Japanese Pharmacological Soc
Erişim Hakkı
info:eu-repo/semantics/openAccess
Özet
Morphine is known to release histamine from mast cells. It is also known that histamine receptors mediate some of morphine's effects on the central nervous system. The contribution of H-1- and H-2-receptors to the effect of morphine on maximal electroconvulsive shock in mice was investigated in the present experiments. Morphine showed a dose-dependent anticonvulsive effect, but produced spontaneous clonic convulsions at higher doses (100 mg/kg, i.p.). The anticonvulsive effect of morphine (1 mg/kg, i.p.) was antagonized by histamine Hi-receptor antagonists, dimethindene (0.1 mg/kg, i.p.), promethazine (0.4 mg/kg, i.p.) and pheniramine (30 mg/kg, i.p.), and naloxone (10 mg/kg, i.p.), but not by the H-2-receptor antagonist ranitidine (10-50 mu g, i.c.v.). These results show that morphine has an anticonvulsive effect via histamine H-1-receptors against maximal electroconvulsive shock in mice.
Açıklama
Anahtar Kelimeler
Morphine, Anticonvulsive Effect, Histamine, Histamine H-1-Receptor, Maximal Electroconvulsive Shock, Central Nervous-System, Mast-Cells, Brain Histamine, Mouse-Brain, Rat, Transmitter, Involvement, Receptors, Turnover, Release
Kaynak
Japanese Journal Of Pharmacology
WoS Q Değeri
N/A
Scopus Q Değeri
N/A
Cilt
71
Sayı
2
