Combined systemic administration of morphine and magnesium sulfate attenuates pain-related behavior in mononeuropathic rats

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dc.authoridUlugol, Ahmet/0000-0003-4643-1124
dc.authoridKaradag, Cetin Hakan/0000-0002-4763-986X
dc.authorwosidUlugol, Ahmet/V-9665-2019
dc.authorwosidKaradag, Cetin Hakan/H-4899-2013
dc.contributor.authorUlugol, A
dc.contributor.authorAslantas, A
dc.contributor.authorIpci, Y
dc.contributor.authorTuncer, A
dc.contributor.authorKaradag, CH
dc.contributor.authorDokmeci, I
dc.date.accessioned2024-06-12T11:09:11Z
dc.date.available2024-06-12T11:09:11Z
dc.date.issued2002
dc.departmentTrakya Üniversitesien_US
dc.description.abstractThe response to opioids is reduced in neuropathic pain states. We examined the effect of the combination of morphine (0.1 mg/kg) and magnesium sulfate (125 mg/kg) on behavioral signs of neuropathic pain in spinal nerve ligated rats. Administered alone, neither drug produced any effect, but the combination exerted a significant anti-allodynic effect, which was partially reversed by naloxone. These results suggest that combining low doses of magnesium sulfate with opiates might be an alternative in treating neuropathic pain, with reduced risk of side effects. (C) 2002 Elsevier Science B.V. All rights reserved.en_US
dc.identifier.doi10.1016/S0006-8993(02)02618-5
dc.identifier.endpage104en_US
dc.identifier.issn0006-8993
dc.identifier.issue1en_US
dc.identifier.pmid12088843en_US
dc.identifier.scopus2-s2.0-0037024943en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage101en_US
dc.identifier.urihttps://doi.org/10.1016/S0006-8993(02)02618-5
dc.identifier.urihttps://hdl.handle.net/20.500.14551/22698
dc.identifier.volume943en_US
dc.identifier.wosWOS:000177021000012en_US
dc.identifier.wosqualityQ2en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherElsevier Science Bven_US
dc.relation.ispartofBrain Researchen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectNeuropathic Painen_US
dc.subjectAllodyniaen_US
dc.subjectMorphineen_US
dc.subjectMagnesiumen_US
dc.subjectNmda-Receptor Antagonistsen_US
dc.subjectNeuropathic Painen_US
dc.subjectPeripheral Neuropathyen_US
dc.subjectSpinal-Corden_US
dc.subjectOpioidsen_US
dc.subjectNeuronsen_US
dc.subjectAntinociceptionen_US
dc.subjectPotentiationen_US
dc.subjectResponsesen_US
dc.subjectModelsen_US
dc.titleCombined systemic administration of morphine and magnesium sulfate attenuates pain-related behavior in mononeuropathic ratsen_US
dc.typeArticleen_US

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