Combined systemic administration of morphine and magnesium sulfate attenuates pain-related behavior in mononeuropathic rats
Küçük Resim Yok
Tarih
2002
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
Elsevier Science Bv
Erişim Hakkı
info:eu-repo/semantics/closedAccess
Özet
The response to opioids is reduced in neuropathic pain states. We examined the effect of the combination of morphine (0.1 mg/kg) and magnesium sulfate (125 mg/kg) on behavioral signs of neuropathic pain in spinal nerve ligated rats. Administered alone, neither drug produced any effect, but the combination exerted a significant anti-allodynic effect, which was partially reversed by naloxone. These results suggest that combining low doses of magnesium sulfate with opiates might be an alternative in treating neuropathic pain, with reduced risk of side effects. (C) 2002 Elsevier Science B.V. All rights reserved.
Açıklama
Anahtar Kelimeler
Neuropathic Pain, Allodynia, Morphine, Magnesium, Nmda-Receptor Antagonists, Neuropathic Pain, Peripheral Neuropathy, Spinal-Cord, Opioids, Neurons, Antinociception, Potentiation, Responses, Models
Kaynak
Brain Research
WoS Q Değeri
Q2
Scopus Q Değeri
Q2
Cilt
943
Sayı
1
