Protective effects of L-arginine on rat terminal ileum subjected to ischemia/reperfusion

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dc.authoridOzacmak, V. Haktan/0000-0003-2651-8353
dc.authoridAktas, Ranan/0000-0002-4474-7371
dc.authoridArslan, Seyfullah Oktay/0000-0001-9328-9373
dc.authoridArslan, Seyfullah Oktay/0000-0001-9328-9373
dc.authorwosidOzacmak, V. Haktan/J-2395-2019
dc.authorwosidAktas, Ranan/F-2910-2016
dc.authorwosidArslan, Seyfullah Oktay/IXN-3383-2023
dc.authorwosidArslan, Seyfullah Oktay/AAE-9538-2019
dc.contributor.authorSayan, Hale
dc.contributor.authorOzacmak, V. Haktan
dc.contributor.authorAltaner, Semsi
dc.contributor.authorAktas, R. Gulhan
dc.contributor.authorArslan, S. Oktay
dc.date.accessioned2024-06-12T10:58:24Z
dc.date.available2024-06-12T10:58:24Z
dc.date.issued2008
dc.departmentTrakya Üniversitesien_US
dc.description.abstractObjectives: Studies have shown that nitric oxide (NO) may play a major role in sustaining mucosal integrity; however, NO has been also implicated in the pathogenesis of ischemia/ reperfusion (I/R)-related tissue injury. We investigated the effects of L-arginine and N-G-nitro L-arginine methyl ester (L-NAME) on the acetylcholine-induced contractile response of ileum and the levels of malondialdehyde (MDA) and reduced glutathione (GSH). Histopathological changes were also evaluated in ileal preparations. Materials and Methods: Mate Wistar Albino rats were subjected to mesenteric ischemia (30 min) followed by reperfusion (3 hours). Four groups were designed: sham-operated control; I/R; I/R and L-arginine pretreatment; and I/ R and L-NAME pretreatment. After reperfusion, ileum specimens were collected to determine the parameters mentioned above. Results: Following reperfusion, a significant decrease in acetylcholine-induced contractile response, an increase in lipid peroxidation, a decrease in GSH content, and mucosal damage of the ileal preparations were observed. We showed that decreased contractility, increased lipid peroxidation, and reduced GSH content have been reversed by L-arginine but not by L-NAME. Mucosal injury was significantly lowered in the L-arginine group. Conclusions: Treatment with L-arginine exerted a protective effect in intestinal I/R injury, which was mediated in part by regulating MDA and GSH levels, consequently ameliorating impaired contractile response and mucosal injury.en_US
dc.identifier.doi10.1097/01.mpg.0000304450.54057.96
dc.identifier.endpage35en_US
dc.identifier.issn0277-2116
dc.identifier.issn1536-4801
dc.identifier.issue1en_US
dc.identifier.pmid18162830en_US
dc.identifier.scopus2-s2.0-37549028477en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.startpage29en_US
dc.identifier.urihttps://doi.org/10.1097/01.mpg.0000304450.54057.96
dc.identifier.urihttps://hdl.handle.net/20.500.14551/20056
dc.identifier.volume46en_US
dc.identifier.wosWOS:000251792200007en_US
dc.identifier.wosqualityQ2en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherLippincott Williams & Wilkinsen_US
dc.relation.ispartofJournal Of Pediatric Gastroenterology And Nutritionen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectContractile Activityen_US
dc.subjectIleumen_US
dc.subjectIschemia And Reperfusionen_US
dc.subjectNitric Oxideen_US
dc.subjectNitric-Oxide Synthaseen_US
dc.subjectIntestinal Ischemia-Reperfusionen_US
dc.subjectIleal Longitudinal Muscleen_US
dc.subjectInjuryen_US
dc.subjectModelen_US
dc.subjectResponsivenessen_US
dc.subjectMotilityen_US
dc.titleProtective effects of L-arginine on rat terminal ileum subjected to ischemia/reperfusionen_US
dc.typeArticleen_US

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