Renal Cortical 68Ga-PSMA-11 PET and 99mTc-DMSA Images

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dc.authoridSarikaya, Ismet/0000-0002-1087-580X
dc.authorwosidSarikaya, Ismet/G-7881-2015
dc.contributor.authorSarikaya, Ismet
dc.contributor.authorAlqallaf, Ahmed
dc.contributor.authorSarikaya, Ali
dc.date.accessioned2024-06-12T10:59:42Z
dc.date.available2024-06-12T10:59:42Z
dc.date.issued2021
dc.departmentTrakya Üniversitesien_US
dc.description.abstractGa-68-prostate-specific membrane antigen (PSMA) ligands are novel PET radiotracers for prostate cancer. These radiotracers also localize in the normal renal cortex to a high degree and can demonstrate parenchymal defects. We recently started a prospective research study to compare Ga-68-PSMA-11 PET/CT with Tc-99m-dimercaptosuccinic acid (DMSA) scan in adults with pyelonephritis. Here, we present a side-by-side comparison of renal cortical PSMA PET/CT and DMSA images of an adult patient with chronic recurring pyelonephritis. Methods: Our prospective study was approved by the Ethical Committees. DMSA images (multiple planar and SPECT) were obtained 3 h after intravenous injection of 111 MBq (3 mCi) of Tc-99m-DMSA. On a separate day, we obtained PET/CT images of the kidneys 60 min after intravenous injection of 74 MBq (2 mCi) of Ga-68-PSMA-11 after the patient provided written informed consent. Results: The patient was a 46-y-old woman with history of chronic recurring pyelonephritis. Both DMSA scan and PSMA PET/CT demonstrated slight cortical thinning with mildly reduced uptake in the upper pole of the right kidney, with no significant cortical defects. There was an excellent distribution of activity in the renal cortex and better image resolution with PSMA PET than with DMSA scan. Non-attenuation-corrected PSMA PET images also showed the same findings, with reasonable image quality. Conclusion: In our first case, Ga-68-PSMA-11 PET imaging provided promising results in an adult patient with pyelonephritis. The results of our prospective study on a larger number of adult patients will provide a more accurate comparison of Ga-68-PSMA-11 PET to Tc-99m-DMSA scanning in pyelonephritis.en_US
dc.identifier.doi10.2967/jnmt.120.248922
dc.identifier.endpage33en_US
dc.identifier.issn0091-4916
dc.identifier.issn1535-5675
dc.identifier.issue1en_US
dc.identifier.pmid32887764en_US
dc.identifier.scopus2-s2.0-85102602898en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.startpage30en_US
dc.identifier.urihttps://doi.org/10.2967/jnmt.120.248922
dc.identifier.urihttps://hdl.handle.net/20.500.14551/20548
dc.identifier.volume49en_US
dc.identifier.wosWOS:000702871200010en_US
dc.identifier.wosqualityN/Aen_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherSoc Nuclear Medicine Incen_US
dc.relation.ispartofJournal Of Nuclear Medicine Technologyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectDMSA Scanen_US
dc.subjectGa-68-PSMAen_US
dc.subjectPETen_US
dc.subjectPyelonephritisen_US
dc.subjectRenal Corticalen_US
dc.subjectMembrane Antigenen_US
dc.subjectProcedure Guidelineen_US
dc.subjectProstateen_US
dc.subjectExpressionen_US
dc.subjectScintigraphyen_US
dc.subjectSpecificityen_US
dc.subjectLiganden_US
dc.titleRenal Cortical 68Ga-PSMA-11 PET and 99mTc-DMSA Imagesen_US
dc.typeArticleen_US

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