Renal Cortical 68Ga-PSMA-11 PET and 99mTc-DMSA Images
Küçük Resim Yok
Tarih
2021
Yazarlar
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
Soc Nuclear Medicine Inc
Erişim Hakkı
info:eu-repo/semantics/openAccess
Özet
Ga-68-prostate-specific membrane antigen (PSMA) ligands are novel PET radiotracers for prostate cancer. These radiotracers also localize in the normal renal cortex to a high degree and can demonstrate parenchymal defects. We recently started a prospective research study to compare Ga-68-PSMA-11 PET/CT with Tc-99m-dimercaptosuccinic acid (DMSA) scan in adults with pyelonephritis. Here, we present a side-by-side comparison of renal cortical PSMA PET/CT and DMSA images of an adult patient with chronic recurring pyelonephritis. Methods: Our prospective study was approved by the Ethical Committees. DMSA images (multiple planar and SPECT) were obtained 3 h after intravenous injection of 111 MBq (3 mCi) of Tc-99m-DMSA. On a separate day, we obtained PET/CT images of the kidneys 60 min after intravenous injection of 74 MBq (2 mCi) of Ga-68-PSMA-11 after the patient provided written informed consent. Results: The patient was a 46-y-old woman with history of chronic recurring pyelonephritis. Both DMSA scan and PSMA PET/CT demonstrated slight cortical thinning with mildly reduced uptake in the upper pole of the right kidney, with no significant cortical defects. There was an excellent distribution of activity in the renal cortex and better image resolution with PSMA PET than with DMSA scan. Non-attenuation-corrected PSMA PET images also showed the same findings, with reasonable image quality. Conclusion: In our first case, Ga-68-PSMA-11 PET imaging provided promising results in an adult patient with pyelonephritis. The results of our prospective study on a larger number of adult patients will provide a more accurate comparison of Ga-68-PSMA-11 PET to Tc-99m-DMSA scanning in pyelonephritis.
Açıklama
Anahtar Kelimeler
DMSA Scan, Ga-68-PSMA, PET, Pyelonephritis, Renal Cortical, Membrane Antigen, Procedure Guideline, Prostate, Expression, Scintigraphy, Specificity, Ligand
Kaynak
Journal Of Nuclear Medicine Technology
WoS Q Değeri
N/A
Scopus Q Değeri
Q3
Cilt
49
Sayı
1
