Synthesis and cytotoxic activities of transition-metal complexes of a binaphthyl-linked bipyridine ligand

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dc.authoridUluçam, Gühergül/0000-0001-6481-8483
dc.authoridBenkli, Kadriye/0000-0002-9042-8718
dc.authorwosidUluçam, Gühergül/AAH-2862-2019
dc.contributor.authorBeynek, Nesrin
dc.contributor.authorUlucam, Gueherguel
dc.contributor.authorBenkli, Kadriye
dc.date.accessioned2024-06-12T11:19:44Z
dc.date.available2024-06-12T11:19:44Z
dc.date.issued2009
dc.departmentTrakya Üniversitesien_US
dc.description.abstractA binaphthyl-linked bipyridyl compound, 1,1'-bis(6-methyl-6'-oxymethylenyl-2,2'-bipyridine)binaphthyl, (L) has been synthesised and used as a ligand for the formation of Cu(II), Ni(II), and Co(II) complexes. The ligand and its transition-metal complexes were characterized by physico-chemical and spectroscopic methods. The complexes were also investigated for cytotoxic activity. The cytotoxicity of complexes, CuL(ClO4)(2), NiL(ClO4)(2)(H2O), CoL(ClO4)(2), were tested in vitro applying seven well-characterized human tumor cell lines, MCF7, EVSA-T, WIDR, IGROV, M19 MEL, A498, H226, and the microculture sulforhodamine B (SRB) test. All complexes show a very high cytotoxicity (ID50 < 250 ng/ml) in these cell lines.en_US
dc.description.sponsorshipCommissions of Scientific Research Projectsen_US
dc.description.sponsorshipThe authors thank Trakya University and Anadolu University, Commissions of Scientific Research Projects and gratefully acknowledge Leiden University for the experimental and theoretical support of this work and for discussions (G. A. van Albada and J. Reedijk). The authors also thank Pharmachemie BV Netherlands, for performing the anticancer tests and recording API-ES mass spectrum and EPR of complexes.en_US
dc.identifier.doi10.1007/s11243-009-9192-1
dc.identifier.endpage292en_US
dc.identifier.issn0340-4285
dc.identifier.issn1572-901X
dc.identifier.issue3en_US
dc.identifier.scopus2-s2.0-62649126116en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage289en_US
dc.identifier.urihttps://doi.org/10.1007/s11243-009-9192-1
dc.identifier.urihttps://hdl.handle.net/20.500.14551/25308
dc.identifier.volume34en_US
dc.identifier.wosWOS:000264267400006en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.language.isoenen_US
dc.publisherSpringeren_US
dc.relation.ispartofTransition Metal Chemistryen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectProteinen_US
dc.titleSynthesis and cytotoxic activities of transition-metal complexes of a binaphthyl-linked bipyridine liganden_US
dc.typeArticleen_US

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