Synthesis and cytotoxic activities of transition-metal complexes of a binaphthyl-linked bipyridine ligand
Küçük Resim Yok
Tarih
2009
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
Springer
Erişim Hakkı
info:eu-repo/semantics/closedAccess
Özet
A binaphthyl-linked bipyridyl compound, 1,1'-bis(6-methyl-6'-oxymethylenyl-2,2'-bipyridine)binaphthyl, (L) has been synthesised and used as a ligand for the formation of Cu(II), Ni(II), and Co(II) complexes. The ligand and its transition-metal complexes were characterized by physico-chemical and spectroscopic methods. The complexes were also investigated for cytotoxic activity. The cytotoxicity of complexes, CuL(ClO4)(2), NiL(ClO4)(2)(H2O), CoL(ClO4)(2), were tested in vitro applying seven well-characterized human tumor cell lines, MCF7, EVSA-T, WIDR, IGROV, M19 MEL, A498, H226, and the microculture sulforhodamine B (SRB) test. All complexes show a very high cytotoxicity (ID50 < 250 ng/ml) in these cell lines.
Açıklama
Anahtar Kelimeler
Protein
Kaynak
Transition Metal Chemistry
WoS Q Değeri
Q3
Scopus Q Değeri
Q2
Cilt
34
Sayı
3
