Involvement of cannabinoid CB1 receptors in the antinociceptive effect of dipyrone

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dc.authoridUlugol, Ahmet/0000-0003-4643-1124
dc.authorwosidUlugol, Ahmet/V-9665-2019
dc.contributor.authorElmas, Pinar
dc.contributor.authorUlugol, Ahmet
dc.date.accessioned2024-06-12T10:59:39Z
dc.date.available2024-06-12T10:59:39Z
dc.date.issued2013
dc.departmentTrakya Üniversitesien_US
dc.description.abstractCannabinoid CB1 receptors have been implicated in the antinociceptive effect of paracetamol. In the current study, we examined whether blockade of CB1 receptors prevent the analgesic activity of dipyrone, in a similar way to paracetamol. Hot-plate and tail-flick tests were used to assess the antinociceptive activity in mice. Dipyrone and WIN 55,212-2, a cannabinoid agonist, exerted significant antinociceptive effects in both hot-plate and tail flick tests. The CB1 receptor antagonist, AM-251 (3 mg/kg), at a dose which had no effect when used alone, did not alter the antinociceptive effect of dipyrone, whereas completely prevented the antinociceptive activity of WIN 55,212-2 in both thermal antinociceptive tests. Our findings suggest that, unlike paracetamol, cannabinoid CB1 receptors do not participate in the antinociceptive action of dipyrone when acute pain tests used.en_US
dc.description.sponsorshipTrakya University Research Council [TUBAP-2012/58]en_US
dc.description.sponsorshipThis work was supported by a grant from Trakya University Research Council (TUBAP-2012/58). The authors have no conflicts of interests to report.en_US
dc.identifier.doi10.1007/s00702-013-1052-7
dc.identifier.endpage1538en_US
dc.identifier.issn0300-9564
dc.identifier.issn1435-1463
dc.identifier.issue11en_US
dc.identifier.pmid23784345en_US
dc.identifier.scopus2-s2.0-84887244709en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage1533en_US
dc.identifier.urihttps://doi.org/10.1007/s00702-013-1052-7
dc.identifier.urihttps://hdl.handle.net/20.500.14551/20518
dc.identifier.volume120en_US
dc.identifier.wosWOS:000326054900003en_US
dc.identifier.wosqualityQ2en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherSpringer Wienen_US
dc.relation.ispartofJournal Of Neural Transmissionen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectDipyroneen_US
dc.subjectWIN 55,212-2en_US
dc.subjectCB1 Receptoren_US
dc.subjectAntinociceptionen_US
dc.subjectPag-Microinjected Dipyroneen_US
dc.subjectEndogenous Opioidsen_US
dc.subjectSpinal-Corden_US
dc.subjectRvm Axisen_US
dc.subjectMetamizolen_US
dc.subjectRatsen_US
dc.subjectMiceen_US
dc.subjectPainen_US
dc.subjectParacetamolen_US
dc.subjectActivationen_US
dc.titleInvolvement of cannabinoid CB1 receptors in the antinociceptive effect of dipyroneen_US
dc.typeArticleen_US

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