Involvement of cannabinoid CB1 receptors in the antinociceptive effect of dipyrone
Küçük Resim Yok
Tarih
2013
Yazarlar
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
Springer Wien
Erişim Hakkı
info:eu-repo/semantics/closedAccess
Özet
Cannabinoid CB1 receptors have been implicated in the antinociceptive effect of paracetamol. In the current study, we examined whether blockade of CB1 receptors prevent the analgesic activity of dipyrone, in a similar way to paracetamol. Hot-plate and tail-flick tests were used to assess the antinociceptive activity in mice. Dipyrone and WIN 55,212-2, a cannabinoid agonist, exerted significant antinociceptive effects in both hot-plate and tail flick tests. The CB1 receptor antagonist, AM-251 (3 mg/kg), at a dose which had no effect when used alone, did not alter the antinociceptive effect of dipyrone, whereas completely prevented the antinociceptive activity of WIN 55,212-2 in both thermal antinociceptive tests. Our findings suggest that, unlike paracetamol, cannabinoid CB1 receptors do not participate in the antinociceptive action of dipyrone when acute pain tests used.
Açıklama
Anahtar Kelimeler
Dipyrone, WIN 55,212-2, CB1 Receptor, Antinociception, Pag-Microinjected Dipyrone, Endogenous Opioids, Spinal-Cord, Rvm Axis, Metamizol, Rats, Mice, Pain, Paracetamol, Activation
Kaynak
Journal Of Neural Transmission
WoS Q Değeri
Q2
Scopus Q Değeri
Q2
Cilt
120
Sayı
11
