THE PROTECTIVE EFFECT OF MOCLOBEMIDE AGAINST HYPOXIA-INDUCED LETHALITY IN MICE IS NOT DUE TO A DECREASE IN BODY-TEMPERATURE
Küçük Resim Yok
Tarih
1995
Yazarlar
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
Pergamon-Elsevier Science Ltd
Erişim Hakkı
info:eu-repo/semantics/closedAccess
Özet
The protective effect of moclobemide, a reversible and highly selective inhibitor of monoamine oxidase-A, against hypoxia-induced lethality was investigated in the present experiment. Moclobemide showed an apparent protective potency against hypoxia and significantly prolonged the latencies for convulsions and death in a dose-dependent manner. Hypothermia is known to protect animals from hypoxia. Moclobemide also decreased body temperature in mice; however, the hypothermic effect was unrelated to the antihypoxic effect. These results suggest that the protective effect of moclobemide in hypoxia is not due to a decrease in body temperature.
Açıklama
Anahtar Kelimeler
MOCLOBEMIDE, HYPOXIA, BODY TEMPERATURE, Oxidase Type-A, Barbiturate Protection, Reversible Inhibitor, Hypothermia, Pharmacology, Profile, Drugs
Kaynak
Pharmacology Biochemistry And Behavior
WoS Q Değeri
N/A
Scopus Q Değeri
Q1
Cilt
51
Sayı
2-3
