Genotoxic and Cytotoxic Evaluation of Pyrethroid Insecticides ?-Cyhalothrin and ?-Cypermethrin on Human Blood Lymphocyte Culture

Simple item page
dc.authoridGokalp, Fulya Dilek/0000-0001-8219-6657
dc.contributor.authorMuranli, Fulya Dilek Gokalp
dc.date.accessioned2024-06-12T11:07:26Z
dc.date.available2024-06-12T11:07:26Z
dc.date.issued2013
dc.departmentTrakya Üniversitesien_US
dc.description.abstractThe present study aimed to investigate the genotoxic, cytotoxic and aneugenic effects of 1, 2, 3.75, 7.5, 15, 30 mu M concentrations of the insecticides lambda-cyhalothrin (LCT) and alpha-cypermethrin (CYP) on human peripheral blood lymphocyte culture using micronucleus (MN) and fluorescence in situ hybridisation (FISH) methods. All the concentrations were tested to assess the MN and apoptosis effects, and 1 and 2 mu M LCT and 7.5 and 15 mu M CYP concentrations were tested for FISH analysis. The cytotoxic effect was also observed using trypan blue and the acridine orange/ethidium bromide fluorescence staining method to measure the apoptotic effect. It was observed that both of the insecticides had a cytotoxic effect at all the concentrations (p a parts per thousand currency sign 0.001) and apoptotic effect for LCT at 15-30 mu M (p a parts per thousand currency sign 0.05; p a parts per thousand currency sign 0.01) for CYP between 2 and 30 mu M concentrations (p a parts per thousand currency sign 0.05; p a parts per thousand currency sign 0.01). The micronuclei that developed after exposure were induced because of an aneugenic effect (p a parts per thousand currency sign 0.001). LCT and CYP might be spindle poisons or caused damaged to centromere/kinetochore function.en_US
dc.description.sponsorshipTrakya University [TUBAP 2008/35]en_US
dc.description.sponsorshipThe work was supported by Trakya University [TUBAP 2008/35 Project].en_US
dc.identifier.doi10.1007/s00128-012-0909-z
dc.identifier.endpage363en_US
dc.identifier.issn0007-4861
dc.identifier.issn1432-0800
dc.identifier.issue3en_US
dc.identifier.pmid23229297en_US
dc.identifier.scopus2-s2.0-84876184439en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage357en_US
dc.identifier.urihttps://doi.org/10.1007/s00128-012-0909-z
dc.identifier.urihttps://hdl.handle.net/20.500.14551/22038
dc.identifier.volume90en_US
dc.identifier.wosWOS:000316002700017en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherSpringeren_US
dc.relation.ispartofBulletin Of Environmental Contamination And Toxicologyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectLambda-Cyhalothrinen_US
dc.subjectAlpha-Cypermethrinen_US
dc.subjectFISHen_US
dc.subjectAneugenic Effecten_US
dc.subjectIn-Vitroen_US
dc.subjectInductionen_US
dc.subjectMicronucleien_US
dc.subjectPesticidesen_US
dc.subjectAneuploidyen_US
dc.subjectVivoen_US
dc.titleGenotoxic and Cytotoxic Evaluation of Pyrethroid Insecticides ?-Cyhalothrin and ?-Cypermethrin on Human Blood Lymphocyte Cultureen_US
dc.typeArticleen_US

Files

Collections

WoS İndeksli Yayınlar Koleksiyonu
PubMed İndeksli Yayınlar Koleksiyonu
Scopus İndeksli Yayınlar Koleksiyonu

We collect and process your personal information for the following purposes: Authentication, Preferences, Acknowledgement and Statistics.
To learn more, please read our privacy policy.

Customize