Electron microscopic immunolocalization of basic fibroblast growth factor in peripheral nerves

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dc.authoridAktas, Ranan/0000-0002-4474-7371
dc.authorwosidAktas, Ranan/F-2910-2016
dc.contributor.authorKayton, RJ
dc.contributor.authorAktas, RG
dc.date.accessioned2024-06-12T10:54:13Z
dc.date.available2024-06-12T10:54:13Z
dc.date.issued2000
dc.departmentTrakya Üniversitesien_US
dc.description.abstractIn spite of ample information about the distribution and the effects of basic fibroblast growth factor (bFGF) in the central nervous system, few data are available concerning the localization of this protein in the peripheral nervous system. In view of the role of bFGF in the regulation of trophic and non-trophic functions, we focused on the presence and precise localization of this growth factor in normal peripheral nerves at the electron microscopic level. The study shows that bFGF is mainly located in the Schwann cells, especially in the nuclei. There is slight labeling in the myelin sheath and in the axon cytoplasm. The study provides morphologic evidence for an association between bFGF expression and Schwann cells. Such an association argues for a role of this peptide in the maintenance or regeneration of peripheral nerves.en_US
dc.identifier.endpage419en_US
dc.identifier.issn0948-6143
dc.identifier.issn1432-119X
dc.identifier.issue5en_US
dc.identifier.pmid11151411en_US
dc.identifier.scopus2-s2.0-0033667505en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.startpage413en_US
dc.identifier.urihttps://hdl.handle.net/20.500.14551/18974
dc.identifier.volume114en_US
dc.identifier.wosWOS:000165752400008en_US
dc.identifier.wosqualityQ1en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherSpringeren_US
dc.relation.ispartofHistochemistry And Cell Biologyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectBasic Fibroblast Growth Factoren_US
dc.subjectImmunoelectron Microscopyen_US
dc.subjectCultured Schwann-Cellsen_US
dc.subjectCentral-Nervous-Systemen_US
dc.subjectSciatic-Nerveen_US
dc.subjectHuman Gliomasen_US
dc.subjectInsulin-Likeen_US
dc.subjectExpressionen_US
dc.subjectProliferationen_US
dc.subjectSecretionen_US
dc.subjectRaten_US
dc.subjectLocalizationen_US
dc.titleElectron microscopic immunolocalization of basic fibroblast growth factor in peripheral nervesen_US
dc.typeArticleen_US

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