Electron microscopic immunolocalization of basic fibroblast growth factor in peripheral nerves
Küçük Resim Yok
Tarih
2000
Yazarlar
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
Springer
Erişim Hakkı
info:eu-repo/semantics/closedAccess
Özet
In spite of ample information about the distribution and the effects of basic fibroblast growth factor (bFGF) in the central nervous system, few data are available concerning the localization of this protein in the peripheral nervous system. In view of the role of bFGF in the regulation of trophic and non-trophic functions, we focused on the presence and precise localization of this growth factor in normal peripheral nerves at the electron microscopic level. The study shows that bFGF is mainly located in the Schwann cells, especially in the nuclei. There is slight labeling in the myelin sheath and in the axon cytoplasm. The study provides morphologic evidence for an association between bFGF expression and Schwann cells. Such an association argues for a role of this peptide in the maintenance or regeneration of peripheral nerves.
Açıklama
Anahtar Kelimeler
Basic Fibroblast Growth Factor, Immunoelectron Microscopy, Cultured Schwann-Cells, Central-Nervous-System, Sciatic-Nerve, Human Gliomas, Insulin-Like, Expression, Proliferation, Secretion, Rat, Localization
Kaynak
Histochemistry And Cell Biology
WoS Q Değeri
Q1
Scopus Q Değeri
Q1
Cilt
114
Sayı
5
