Cellular reactive oxygen species inhibitory constituents of Hypericum thasium Griseb

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dc.authoridMesaik, M. Ahmed/0000-0003-2010-2568
dc.authoridChoudhary, M. Iqbal/0000-0001-5356-3585
dc.authorwosidchaudhary, Muhammad iqbal/E-8638-2015
dc.authorwosidMesaik, M. Ahmed/GRE-9332-2022
dc.authorwosidChoudhary, M. Iqbal/C-8633-2012
dc.contributor.authorDemirkiran, Ozlem
dc.contributor.authorMesaik, M. Ahmed
dc.contributor.authorBeynek, Hayrettin
dc.contributor.authorAbbaskhan, Ahmed
dc.contributor.authorChoudhary, M. Iqbal
dc.date.accessioned2024-06-12T11:03:35Z
dc.date.available2024-06-12T11:03:35Z
dc.date.issued2009
dc.departmentTrakya Üniversitesien_US
dc.description.abstractThe phytochemical investigation of the ethyl acetate extract of Hypericum thasium has led to the characterization of four benzophenone derivatives 1-4, a known benzophenone 5 and four known flavonoids, quercetin (6), quercitrin (7), isoquercetin (8), and 3, 8-biapigenin (9). Lucigenin- and luminal-based chemiluminescence assays were employed to monitor the inhibitory activity of these compounds towards the production of reactive oxygen species (ROS) by human polymorphoneutrophils (PMNs). The assay results showed that benzophenones 1 and 3 are extracellular inhibitors of ROS production, while flavonoids 6, 8, and 9 can modulate intracellular ROS production. (C) 2008 Elsevier Ltd. All rights reserved.en_US
dc.description.sponsorshipChemical and Biological Sciences (Pakistan)en_US
dc.description.sponsorshipOne of the authors (Ozlem Demirkiran) is grateful to the H.E.J. Research Institute of Chemistry, International Center for Chemical and Biological Sciences (Pakistan) for financial support and providing access to excellent research facilities.en_US
dc.identifier.doi10.1016/j.phytochem.2008.10.006
dc.identifier.endpage249en_US
dc.identifier.issn0031-9422
dc.identifier.issue2en_US
dc.identifier.pmid19203769en_US
dc.identifier.scopus2-s2.0-60249099566en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.startpage244en_US
dc.identifier.urihttps://doi.org/10.1016/j.phytochem.2008.10.006
dc.identifier.urihttps://hdl.handle.net/20.500.14551/21698
dc.identifier.volume70en_US
dc.identifier.wosWOS:000264584000012en_US
dc.identifier.wosqualityQ1en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherPergamon-Elsevier Science Ltden_US
dc.relation.ispartofPhytochemistryen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectHypericum Thasiumen_US
dc.subjectGuttiferaeen_US
dc.subjectBenzophenone Glycosidesen_US
dc.subjectReactive Oxygen Species (ROS)en_US
dc.subjectInhibition Of ROSen_US
dc.subjectChemi-Luminescenceen_US
dc.subjectC-13 Nmren_US
dc.subjectBenzophenoneen_US
dc.subjectGlycosidesen_US
dc.subjectChemiluminescenceen_US
dc.subjectAntioxidanten_US
dc.subjectDerivativesen_US
dc.subjectFlavonoidsen_US
dc.subjectAssignmenten_US
dc.subjectXanthonesen_US
dc.titleCellular reactive oxygen species inhibitory constituents of Hypericum thasium Griseben_US
dc.typeArticleen_US

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