Cellular reactive oxygen species inhibitory constituents of Hypericum thasium Griseb
Küçük Resim Yok
Tarih
2009
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
Pergamon-Elsevier Science Ltd
Erişim Hakkı
info:eu-repo/semantics/closedAccess
Özet
The phytochemical investigation of the ethyl acetate extract of Hypericum thasium has led to the characterization of four benzophenone derivatives 1-4, a known benzophenone 5 and four known flavonoids, quercetin (6), quercitrin (7), isoquercetin (8), and 3, 8-biapigenin (9). Lucigenin- and luminal-based chemiluminescence assays were employed to monitor the inhibitory activity of these compounds towards the production of reactive oxygen species (ROS) by human polymorphoneutrophils (PMNs). The assay results showed that benzophenones 1 and 3 are extracellular inhibitors of ROS production, while flavonoids 6, 8, and 9 can modulate intracellular ROS production. (C) 2008 Elsevier Ltd. All rights reserved.
Açıklama
Anahtar Kelimeler
Hypericum Thasium, Guttiferae, Benzophenone Glycosides, Reactive Oxygen Species (ROS), Inhibition Of ROS, Chemi-Luminescence, C-13 Nmr, Benzophenone, Glycosides, Chemiluminescence, Antioxidant, Derivatives, Flavonoids, Assignment, Xanthones
Kaynak
Phytochemistry
WoS Q Değeri
Q1
Scopus Q Değeri
Q1
Cilt
70
Sayı
2
