Factors affecting response rates after thymectomy for myasthenia gravis

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dc.authoridkaramustafaoglu, yekta altemur/0000-0002-5491-1219
dc.authoridYANIK, FAZLI/0000-0002-8931-5329
dc.authorwosidkaramustafaoglu, yekta altemur/S-9512-2019
dc.authorwosidYoruk, Yener/W-4285-2017
dc.authorwosidYanık, Fazlı/W-4597-2017
dc.contributor.authorYanik, Fazli
dc.contributor.authorKaramustafaoglu, Yekta A.
dc.contributor.authorYoruk, Yener
dc.date.accessioned2024-06-12T11:08:55Z
dc.date.available2024-06-12T11:08:55Z
dc.date.issued2018
dc.departmentTrakya Üniversitesien_US
dc.description.abstractAim: In our study, we report the clinical response obtained after transsternal extended thymectomy (TSET), the factors affecting the response, and the most appropriate timing of the operation. Material and Method: A total of 35 cases underwent TSET with the diagnosis of myasthenia gravis in our department from December 1996-June 2015. Twenty of the cases were females (57%) and fifteen (43%) were males with a mean age of 42 +/- 15 (14-68). The case registry has been analyzed retrospectively. Results: Postoperative histopathological examination revealed non-thymoma thymic pathologies in 19 (54%), thymoma in 16 (46%). Myasthenia gravis symptoms were staged according to the Osserman classification: 8 (22,9%) were stage I, 13 (37,1%) were stage IIa, 11 (31,4%) were stage IIb, and 3 (8,6%) were stage III, with no patients at stage IV. The duration of symptoms of <24 month before the operation was statistically significant for groups with and without thymoma (p<0,001). However, parameters of age, gender, preoperative Osserman stage, and pathological diagnosis were not statistically significant between groups. Discussion: Transsternal extended thymectomy allows for extended removal of all the mediastinal tissue in the anterior mediastinum with a low complication rate. Symptom duration before operation is the most important factor in response to treatment; therefore, patients must be operated on as soon as possible. Thymectomy also seems to be helpful for early stage MG.en_US
dc.identifier.doi10.4328/JCAM.5811
dc.identifier.endpage438en_US
dc.identifier.issn1309-0720
dc.identifier.issn1309-2014
dc.identifier.issue5en_US
dc.identifier.startpage434en_US
dc.identifier.urihttps://doi.org/10.4328/JCAM.5811
dc.identifier.urihttps://hdl.handle.net/20.500.14551/22601
dc.identifier.volume9en_US
dc.identifier.wosWOS:000435652100016en_US
dc.identifier.wosqualityN/Aen_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.language.isoenen_US
dc.publisherDerman Medical Publen_US
dc.relation.ispartofJournal Of Clinical And Analytical Medicineen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectMyastheniaen_US
dc.subjectSurgeryen_US
dc.subjectThymectomyen_US
dc.subjectTranscervical Thymectomyen_US
dc.subjectTranssternal Thymectomyen_US
dc.subjectExtended Thymectomyen_US
dc.subjectMaximal Thymectomyen_US
dc.subjectFollow-Upen_US
dc.subjectAntibodiesen_US
dc.subjectExperienceen_US
dc.subjectTitinen_US
dc.titleFactors affecting response rates after thymectomy for myasthenia gravisen_US
dc.typeArticleen_US

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