Factors affecting response rates after thymectomy for myasthenia gravis
Küçük Resim Yok
Tarih
2018
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
Derman Medical Publ
Erişim Hakkı
info:eu-repo/semantics/openAccess
Özet
Aim: In our study, we report the clinical response obtained after transsternal extended thymectomy (TSET), the factors affecting the response, and the most appropriate timing of the operation. Material and Method: A total of 35 cases underwent TSET with the diagnosis of myasthenia gravis in our department from December 1996-June 2015. Twenty of the cases were females (57%) and fifteen (43%) were males with a mean age of 42 +/- 15 (14-68). The case registry has been analyzed retrospectively. Results: Postoperative histopathological examination revealed non-thymoma thymic pathologies in 19 (54%), thymoma in 16 (46%). Myasthenia gravis symptoms were staged according to the Osserman classification: 8 (22,9%) were stage I, 13 (37,1%) were stage IIa, 11 (31,4%) were stage IIb, and 3 (8,6%) were stage III, with no patients at stage IV. The duration of symptoms of <24 month before the operation was statistically significant for groups with and without thymoma (p<0,001). However, parameters of age, gender, preoperative Osserman stage, and pathological diagnosis were not statistically significant between groups. Discussion: Transsternal extended thymectomy allows for extended removal of all the mediastinal tissue in the anterior mediastinum with a low complication rate. Symptom duration before operation is the most important factor in response to treatment; therefore, patients must be operated on as soon as possible. Thymectomy also seems to be helpful for early stage MG.
Açıklama
Anahtar Kelimeler
Myasthenia, Surgery, Thymectomy, Transcervical Thymectomy, Transsternal Thymectomy, Extended Thymectomy, Maximal Thymectomy, Follow-Up, Antibodies, Experience, Titin
Kaynak
Journal Of Clinical And Analytical Medicine
WoS Q Değeri
N/A
Scopus Q Değeri
Cilt
9
Sayı
5
