Involvement of descending serotonergic and noradrenergic pathways in CB1 receptor-mediated antinociception

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dc.authoridUlugol, Ahmet/0000-0003-4643-1124
dc.authorwosidYalcin, Bulent/F-9517-2012
dc.authorwosidYalcin, Bulent/HIK-0062-2022
dc.authorwosidUlugol, Ahmet/V-9665-2019
dc.contributor.authorDogrul, Ahmet
dc.contributor.authorSeyrek, Melik
dc.contributor.authorYalcin, Bulent
dc.contributor.authorUlugol, Ahmet
dc.date.accessioned2024-06-12T10:51:36Z
dc.date.available2024-06-12T10:51:36Z
dc.date.issued2012
dc.departmentTrakya Üniversitesien_US
dc.description.abstractCannabinoids produce antinociceptive and antihyperalgesic effects mainly through activation of the inhibitory CB1 receptors. The demonstration that antinociceptive effects of systemic cannabinoids are significantly diminished following surgical dorsolateral funiculus lesion provides evidence that supraspinal sites and descending pain modulatory pathways play crucial roles in systemic cannabinoid analgesia. In this review, we will firstly provide a background, brief overview of descending modulatory pathways followed by descending pathways implicated in cannabinoid analgesia. We will then describe the recent evidence of the involvement of descending serotonergic and noradrenergic pathways in CB1 receptor-mediated antinociception. This review will provide evidences that systemically administered cannabinoids reinforce the descending serotonergic and noradrenergic pathways to produce acute antinociceptive effects via spinal 5-HT7, 5-HT2A and alpha-2 adrenoceptors activation. (C) 2012 Elsevier Inc. All rights reserved.en_US
dc.identifier.doi10.1016/j.pnpbp.2012.01.007
dc.identifier.endpage105en_US
dc.identifier.issn0278-5846
dc.identifier.issn1878-4216
dc.identifier.issue1en_US
dc.identifier.pmid22300745en_US
dc.identifier.scopus2-s2.0-84862903341en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.startpage97en_US
dc.identifier.urihttps://doi.org/10.1016/j.pnpbp.2012.01.007
dc.identifier.urihttps://hdl.handle.net/20.500.14551/18405
dc.identifier.volume38en_US
dc.identifier.wosWOS:000307258200012en_US
dc.identifier.wosqualityQ1en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherPergamon-Elsevier Science Ltden_US
dc.relation.ispartofProgress In Neuro-Psychopharmacology & Biological Psychiatryen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectAnalgesiaen_US
dc.subjectCannabinoiden_US
dc.subjectDescending Pathwaysen_US
dc.subjectEndocannabinoiden_US
dc.subjectNoradrenalineen_US
dc.subjectSerotoninen_US
dc.subjectCannabinoid-Induced Antinociceptionen_US
dc.subjectNucleus Raphe Magnusen_US
dc.subjectVentromedial Medulla Neuronsen_US
dc.subjectPeriaqueductal Grayen_US
dc.subjectDorsal Rapheen_US
dc.subjectLocus-Coeruleusen_US
dc.subjectSpinal 5-Ht7en_US
dc.subjectEndocannabinoid Systemen_US
dc.subjectPain Modulationen_US
dc.subjectTactile Allodyniaen_US
dc.titleInvolvement of descending serotonergic and noradrenergic pathways in CB1 receptor-mediated antinociceptionen_US
dc.typeReview Articleen_US

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