Involvement of descending serotonergic and noradrenergic pathways in CB1 receptor-mediated antinociception
Küçük Resim Yok
Tarih
2012
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
Pergamon-Elsevier Science Ltd
Erişim Hakkı
info:eu-repo/semantics/closedAccess
Özet
Cannabinoids produce antinociceptive and antihyperalgesic effects mainly through activation of the inhibitory CB1 receptors. The demonstration that antinociceptive effects of systemic cannabinoids are significantly diminished following surgical dorsolateral funiculus lesion provides evidence that supraspinal sites and descending pain modulatory pathways play crucial roles in systemic cannabinoid analgesia. In this review, we will firstly provide a background, brief overview of descending modulatory pathways followed by descending pathways implicated in cannabinoid analgesia. We will then describe the recent evidence of the involvement of descending serotonergic and noradrenergic pathways in CB1 receptor-mediated antinociception. This review will provide evidences that systemically administered cannabinoids reinforce the descending serotonergic and noradrenergic pathways to produce acute antinociceptive effects via spinal 5-HT7, 5-HT2A and alpha-2 adrenoceptors activation. (C) 2012 Elsevier Inc. All rights reserved.
Açıklama
Anahtar Kelimeler
Analgesia, Cannabinoid, Descending Pathways, Endocannabinoid, Noradrenaline, Serotonin, Cannabinoid-Induced Antinociception, Nucleus Raphe Magnus, Ventromedial Medulla Neurons, Periaqueductal Gray, Dorsal Raphe, Locus-Coeruleus, Spinal 5-Ht7, Endocannabinoid System, Pain Modulation, Tactile Allodynia
Kaynak
Progress In Neuro-Psychopharmacology & Biological Psychiatry
WoS Q Değeri
Q1
Scopus Q Değeri
Q1
Cilt
38
Sayı
1
