Involvement of descending serotonergic and noradrenergic pathways in CB1 receptor-mediated antinociception
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Date
2012
Journal Title
Journal ISSN
Volume Title
Publisher
Pergamon-Elsevier Science Ltd
Access Rights
info:eu-repo/semantics/closedAccess
Abstract
Cannabinoids produce antinociceptive and antihyperalgesic effects mainly through activation of the inhibitory CB1 receptors. The demonstration that antinociceptive effects of systemic cannabinoids are significantly diminished following surgical dorsolateral funiculus lesion provides evidence that supraspinal sites and descending pain modulatory pathways play crucial roles in systemic cannabinoid analgesia. In this review, we will firstly provide a background, brief overview of descending modulatory pathways followed by descending pathways implicated in cannabinoid analgesia. We will then describe the recent evidence of the involvement of descending serotonergic and noradrenergic pathways in CB1 receptor-mediated antinociception. This review will provide evidences that systemically administered cannabinoids reinforce the descending serotonergic and noradrenergic pathways to produce acute antinociceptive effects via spinal 5-HT7, 5-HT2A and alpha-2 adrenoceptors activation. (C) 2012 Elsevier Inc. All rights reserved.
Description
Keywords
Analgesia, Cannabinoid, Descending Pathways, Endocannabinoid, Noradrenaline, Serotonin, Cannabinoid-Induced Antinociception, Nucleus Raphe Magnus, Ventromedial Medulla Neurons, Periaqueductal Gray, Dorsal Raphe, Locus-Coeruleus, Spinal 5-Ht7, Endocannabinoid System, Pain Modulation, Tactile Allodynia
Journal or Series
Progress In Neuro-Psychopharmacology & Biological Psychiatry
WoS Q Value
Q1
Scopus Q Value
Q1
Volume
38
Issue
1
