Protection by L-carnitine against radiation-induced ileal mucosal injury in the rat: Pattern of oxidative stress, apoptosis and cytokines

Basit Öğe Kaydı
dc.authoridAkpolat Ferah, Meryem/0000-0002-3419-1728
dc.authoridARASLI, MEHMET/0000-0002-5931-419X
dc.authorwosidAkpolat Ferah, Meryem/ABD-3035-2020
dc.contributor.authorAkpolat, Meryem
dc.contributor.authorGulle, Kanat
dc.contributor.authorTopcu-Tarladacalisir, Yeter
dc.contributor.authorOz, Zehra Safi
dc.contributor.authorBakkal, Bekir Hakan
dc.contributor.authorArasli, Mehmet
dc.contributor.authorTurkcu, Ummuhani Ozel
dc.date.accessioned2024-06-12T11:13:22Z
dc.date.available2024-06-12T11:13:22Z
dc.date.issued2013
dc.departmentTrakya Üniversitesien_US
dc.description.abstractPurpose : In this study, we tested the effects of L-carnitine (LC) on radiation-induced ileal mucosal damage. Materials and methods : Thirty Wistar albino rats were divided into five groups. The control group received physiological saline intraperitoneally (i.p.). Radiation-1 and radiation-2 groups received whole-body X-irradiation of 8.3 Gy as a single dose. These groups were sacrificed at the 6th hour and 4th day after irradiation, respectively. The Radiation-1 + LC and the radiation-2 + LC groups received the same dose irradiation plus a daily dose of 200 mg/kg LC. LC was applied one day before and for four days after irradiation. Results : The levels of serum monocyte chemotactic protein-1 (MCP-1) and interferon gamma (IFN-gamma) were significantly higher in the radiation groups when compared with the control. Treatment with LC decreased the serum MCP-1 and IFN-gamma levels considerably. In the radiations groups, the Chiu score was significantly elevated compared with that of the control group. However, LC administered prior to the irradiation reduced the severity of mucosal damage. The number of apoptotic cells of the ileal crypt in the irradiated rats increased from the 6th hour after irradiation and then decreased at 4th day. Conclusions : Our data demonstrated that LC may be beneficial to radiation enteritis.en_US
dc.identifier.doi10.3109/09553002.2013.787176
dc.identifier.endpage740en_US
dc.identifier.issn0955-3002
dc.identifier.issn1362-3095
dc.identifier.issue9en_US
dc.identifier.pmid23510242en_US
dc.identifier.scopus2-s2.0-84883475929en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage732en_US
dc.identifier.urihttps://doi.org/10.3109/09553002.2013.787176
dc.identifier.urihttps://hdl.handle.net/20.500.14551/23519
dc.identifier.volume89en_US
dc.identifier.wosWOS:000323943100007en_US
dc.identifier.wosqualityQ1en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherTaylor & Francis Ltden_US
dc.relation.ispartofInternational Journal Of Radiation Biologyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectRadiotherapyen_US
dc.subjectIntestineen_US
dc.subjectApoptosisen_US
dc.subjectCytokineen_US
dc.subjectOxidative Stressen_US
dc.subjectHistopathologyen_US
dc.subjectAcetyl-L-Carnitineen_US
dc.subjectGamma-Irradiationen_US
dc.subjectGastrointestinal-Tracten_US
dc.subjectSmall-Intestineen_US
dc.subjectVitamin-Een_US
dc.subjectExpressionen_US
dc.subjectDamageen_US
dc.subjectCellsen_US
dc.subjectInflammationen_US
dc.subjectMyeloperoxidaseen_US
dc.titleProtection by L-carnitine against radiation-induced ileal mucosal injury in the rat: Pattern of oxidative stress, apoptosis and cytokinesen_US
dc.typeArticleen_US

Dosyalar

Koleksiyon

WoS İndeksli Yayınlar Koleksiyonu
PubMed İndeksli Yayınlar Koleksiyonu
Scopus İndeksli Yayınlar Koleksiyonu