Protection by L-carnitine against radiation-induced ileal mucosal injury in the rat: Pattern of oxidative stress, apoptosis and cytokines
Küçük Resim Yok
Tarih
2013
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
Taylor & Francis Ltd
Erişim Hakkı
info:eu-repo/semantics/closedAccess
Özet
Purpose : In this study, we tested the effects of L-carnitine (LC) on radiation-induced ileal mucosal damage. Materials and methods : Thirty Wistar albino rats were divided into five groups. The control group received physiological saline intraperitoneally (i.p.). Radiation-1 and radiation-2 groups received whole-body X-irradiation of 8.3 Gy as a single dose. These groups were sacrificed at the 6th hour and 4th day after irradiation, respectively. The Radiation-1 + LC and the radiation-2 + LC groups received the same dose irradiation plus a daily dose of 200 mg/kg LC. LC was applied one day before and for four days after irradiation. Results : The levels of serum monocyte chemotactic protein-1 (MCP-1) and interferon gamma (IFN-gamma) were significantly higher in the radiation groups when compared with the control. Treatment with LC decreased the serum MCP-1 and IFN-gamma levels considerably. In the radiations groups, the Chiu score was significantly elevated compared with that of the control group. However, LC administered prior to the irradiation reduced the severity of mucosal damage. The number of apoptotic cells of the ileal crypt in the irradiated rats increased from the 6th hour after irradiation and then decreased at 4th day. Conclusions : Our data demonstrated that LC may be beneficial to radiation enteritis.
Açıklama
Anahtar Kelimeler
Radiotherapy, Intestine, Apoptosis, Cytokine, Oxidative Stress, Histopathology, Acetyl-L-Carnitine, Gamma-Irradiation, Gastrointestinal-Tract, Small-Intestine, Vitamin-E, Expression, Damage, Cells, Inflammation, Myeloperoxidase
Kaynak
International Journal Of Radiation Biology
WoS Q Değeri
Q1
Scopus Q Değeri
Q2
Cilt
89
Sayı
9
