A morphological study of uterine alterations in mice due to exposure to cadmium

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dc.authoridAtan, Şenay Unsal/0000-0002-5119-5704
dc.authorwosidAtan, Şenay Unsal/A-1361-2019
dc.contributor.authorSapmaz-Metin, M.
dc.contributor.authorTopcu-Tarladacalisir, Y.
dc.contributor.authorKurt-Omurlu, I.
dc.contributor.authorWeller, B. Karaoz
dc.contributor.authorUnsal-Atan, S.
dc.date.accessioned2024-06-12T10:52:21Z
dc.date.available2024-06-12T10:52:21Z
dc.date.issued2017
dc.departmentTrakya Üniversitesien_US
dc.description.abstractWe investigated the morphologic and molecular effects of exposure to cadmium (Cd) for 30 and 60 days on the uteri of mice. We assessed uterine morphometric measurements, eosinophilia, mast cell numbers, endometrial apoptosis, proliferation and estrogen receptor alpha (ER) immunoreactivity. We examined vaginal smears that reflected the hormonal alterations in the female reproductive tract. Because the female reproductive tract exhibits different morphology at each stage of the estrous cycle, we sacrificed all animals at estrus to make appropriate comparisons. Female BALB/c mice were exposed to 200 ppm Cd in their drinking water for either 30 or 60 days. Cd exposure caused significant decreases in endometrial thickness and number of glands in estrus phase uteri. The endometrial eosinophilia in the groups exposed to Cd also decreased compared to controls. Cd exposure increased the number of mast cells. Luminal and glandular epithelia were examined using the terminal deoxynucleotidyl transferase dUTP nick end labeling (TUNEL) assay and by immunostaining proliferating cell nuclear antigen (PCNA) and estrogen receptor (ER). Compared to controls, the apoptotic index increased with time in both Cd exposed groups, while the proliferation index decreased. ER immunoreactivity was decreased in both Cd exposed groups compared to controls; the decrease was most apparent in the 30 day Cd group. We found that 60 day Cd exposure increased apoptosis in the endometrium, which may affect the receptivity of the uterus for implantation.en_US
dc.identifier.doi10.1080/10520295.2017.1305500
dc.identifier.endpage273en_US
dc.identifier.issn1052-0295
dc.identifier.issn1473-7760
dc.identifier.issue4en_US
dc.identifier.pmid28426261en_US
dc.identifier.scopus2-s2.0-85018514391en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage264en_US
dc.identifier.urihttps://doi.org/10.1080/10520295.2017.1305500
dc.identifier.urihttps://hdl.handle.net/20.500.14551/18682
dc.identifier.volume92en_US
dc.identifier.wosWOS:000401560000003en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherTaylor & Francis Incen_US
dc.relation.ispartofBiotechnic & Histochemistryen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectApoptosisen_US
dc.subjectCadmiumen_US
dc.subjectEstrogen Receptoren_US
dc.subjectMiceen_US
dc.subjectProliferating Cell Nuclear Antigenen_US
dc.subjectUterusen_US
dc.subjectOxidative Stressen_US
dc.subjectEstrogen-Receptoren_US
dc.subjectRat Uterusen_US
dc.subjectIn-Vivoen_US
dc.subjectRenal Toxicityen_US
dc.subjectMast-Cellsen_US
dc.subjectPathwayen_US
dc.subjectMechanismen_US
dc.subjectKinaseen_US
dc.subjectDeathen_US
dc.titleA morphological study of uterine alterations in mice due to exposure to cadmiumen_US
dc.typeArticleen_US

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