Antibacterial, antifungal and antimycobacterial activities of some pyrazoline, hydrazone and chalcone derivatives
Küçük Resim Yok
Tarih
2015
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
Walter De Gruyter Gmbh
Erişim Hakkı
info:eu-repo/semantics/openAccess
Özet
Twenty-seven previously reported chalcones and their pyrazoline and hydrazone derivatives as well as two further chalcones have been screened for their antimicrobial, antifungal and antimycobacterial activities against standard microbial strains and drug resistant isolates. The minimum inhibitory concentration (MIC) value of each compound was determined by a two-fold serial microdilution technique. The compounds were found to possess a broad spectrum of antimicrobial activities with MIC values of 8-128 mu g/mL. One compound [(E)-1(4-hydroxyphenyl)-3-p-tolylprop-2-en-1-one] had equal activity with gentamycin (8 mu g/mL) against Enterococcus faecalis. Chalcones were found to be more active than their hydrazone and 2-pyrazoline derivatives against Staphylococcus aureus ATCC 29213 and E. faecalis ATCC 29212.
Açıklama
Anahtar Kelimeler
Chalcones, Hydrazones, 2-Pyrazolines, Monoamine-Oxidase, Amine Oxidase, In-Vitro, Inhibitory Properties, Escherichia-Coli, Crystallization, Purification, Tuberculosis
Kaynak
Zeitschrift Fur Naturforschung Section C-A Journal Of Biosciences
WoS Q Değeri
Q4
Scopus Q Değeri
Q3
Cilt
70
Sayı
7-8
