Lipoprotein(a) Gene Polymorphism Increases a Risk Factor for Aortic Valve Calcification

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dc.authoridÖzkan, Uğur/0000-0002-7552-7654
dc.authoridbudak, metin/0000-0002-5968-2048
dc.authorwosidÖzkan, Uğur/ACR-6091-2022
dc.authorwosidYILDIZ, Mustafa/P-9934-2015
dc.authorwosidYILDIZ, Mustafa/B-7520-2016
dc.authorwosidBudak, metin/Z-3010-2019
dc.contributor.authorOzkan, Ugur
dc.contributor.authorOzcelik, Fatih
dc.contributor.authorYildiz, Mustafa
dc.contributor.authorBudak, Metin
dc.date.accessioned2024-06-12T11:07:52Z
dc.date.available2024-06-12T11:07:52Z
dc.date.issued2019
dc.departmentTrakya Üniversitesien_US
dc.description.abstractCalcific aortic valve disease (CAVD) is a multifactorial condition. Both environmental and genetic factors play an important role in its etiology. CAVD exhibits a broad spectrum, varying from mild valve thickening to severe valve calcification and stenosis. Progression of the disease consists of chronic inflammation, lipoprotein deposition, and active leaflet calcification. It is a process similar to coronary artery disease. In this study, we investigated Lp(a) levels and gene polymorphisms associated with calcific aortic stenosis from blood samples after echocardiography in the evaluation of 75 patients diagnosed with CAVD and 77 controls. Blood tests were run in our laboratory to rule out certain risk factors before echocardiography examination. A significant association among smoking, elevated LDL level and creatinine, low albumin levels, Lp(a) level, rs10455872, and rs3798220 polymorphisms may be considered genetic risk factors for the development of calcific aortic stenosis.en_US
dc.description.sponsorshipScientific Research Projects Management Unit of Trakya University-Turkey-Project [TUBAP 2016/81]en_US
dc.description.sponsorshipThis work was supported by the Scientific Research Projects Management Unit of Trakya University-Turkey-Project Grant number: TUBAP 2016/81.en_US
dc.identifier.doi10.3390/jcdd6030031
dc.identifier.issn2308-3425
dc.identifier.issue3en_US
dc.identifier.pmid31455005en_US
dc.identifier.scopus2-s2.0-85095731000en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.urihttps://doi.org/10.3390/jcdd6030031
dc.identifier.urihttps://hdl.handle.net/20.500.14551/22205
dc.identifier.volume6en_US
dc.identifier.wosWOS:000488115800007en_US
dc.identifier.wosqualityN/Aen_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherMdpien_US
dc.relation.ispartofJournal Of Cardiovascular Development And Diseaseen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectLp(A) Levelen_US
dc.subjectRs10455872en_US
dc.subjectRs3798220en_US
dc.subjectCalcific Aortic Valve Stenosisen_US
dc.subjectValvular Heart-Diseaseen_US
dc.subjectStenosisen_US
dc.subjectPlasminogenen_US
dc.subjectAssociationen_US
dc.subjectProgressionen_US
dc.subjectInhibitoren_US
dc.subjectFrequencyen_US
dc.subjectMilden_US
dc.titleLipoprotein(a) Gene Polymorphism Increases a Risk Factor for Aortic Valve Calcificationen_US
dc.typeArticleen_US

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