Lipoprotein(a) Gene Polymorphism Increases a Risk Factor for Aortic Valve Calcification
Küçük Resim Yok
Tarih
2019
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
Mdpi
Erişim Hakkı
info:eu-repo/semantics/openAccess
Özet
Calcific aortic valve disease (CAVD) is a multifactorial condition. Both environmental and genetic factors play an important role in its etiology. CAVD exhibits a broad spectrum, varying from mild valve thickening to severe valve calcification and stenosis. Progression of the disease consists of chronic inflammation, lipoprotein deposition, and active leaflet calcification. It is a process similar to coronary artery disease. In this study, we investigated Lp(a) levels and gene polymorphisms associated with calcific aortic stenosis from blood samples after echocardiography in the evaluation of 75 patients diagnosed with CAVD and 77 controls. Blood tests were run in our laboratory to rule out certain risk factors before echocardiography examination. A significant association among smoking, elevated LDL level and creatinine, low albumin levels, Lp(a) level, rs10455872, and rs3798220 polymorphisms may be considered genetic risk factors for the development of calcific aortic stenosis.
Açıklama
Anahtar Kelimeler
Lp(A) Level, Rs10455872, Rs3798220, Calcific Aortic Valve Stenosis, Valvular Heart-Disease, Stenosis, Plasminogen, Association, Progression, Inhibitor, Frequency, Mild
Kaynak
Journal Of Cardiovascular Development And Disease
WoS Q Değeri
N/A
Scopus Q Değeri
Q1
Cilt
6
Sayı
3
