The adriamycin rat/mouse model and its importance to the embryology

Basit Öğe Kaydı
dc.authorscopusid8583021500
dc.authorscopusid22134674200
dc.authorscopusid6506066874
dc.authorscopusid25643338300
dc.authorscopusid55487166200
dc.contributor.authorUz Y.H.
dc.contributor.authorKizilay G.
dc.contributor.authorAkpolat M.
dc.contributor.authorTopçu Tarladaçalişir Y.
dc.contributor.authorSapmaz Metin M.
dc.date.accessioned2024-06-12T10:29:25Z
dc.date.available2024-06-12T10:29:25Z
dc.date.issued2012
dc.description.abstractRat and mouse models induced by the teratogenic effect of adriamycin are reliable and easly reproducible methods of studying the embryology and molecular biology of a range of complex congenital anomalies similar to those seen in humans with VACTERL association. The mechanism by which adriamycin produces the congenital anomalies found in the VACTERL association is not yet clear. Studies with these models have focused on mainly abnormal notochord morphology, shedding more light on the important role of this structure in the developing embryo. Morover, defective Shh signaling pathway is another emphasized mechanism. This review aims to discuss adriamycin rat and mouse models and their impact on congenital anomalies similar to those seen in humans with VACTERL association, in the light of current literature data. © 2012 Düzce Medical Journal.en_US
dc.identifier.endpage56en_US
dc.identifier.issn1307-671X
dc.identifier.issue2en_US
dc.identifier.scopus2-s2.0-84869233332en_US
dc.identifier.scopusqualityQ4en_US
dc.identifier.startpage51en_US
dc.identifier.urihttps://hdl.handle.net/20.500.14551/17753
dc.identifier.volume14en_US
dc.indekslendigikaynakScopusen_US
dc.language.isoenen_US
dc.publisherDuzce University Medical Schoolen_US
dc.relation.ispartofDuzce Medical Journalen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectAdriamycin; Mouse; Notochord; Rat; Vacterlen_US
dc.subjectDoxorubicin; Adverse Outcome; Congenital Malformation; Embryo Development; Embryotoxicity; Mouse; Nonhuman; Rat; Review; Syndrome Vateren_US
dc.titleThe adriamycin rat/mouse model and its importance to the embryologyen_US
dc.title.alternativeAdriyamisin sıçan/fare modeli ve embriyolojide önemien_US
dc.typeReview Articleen_US

Dosyalar

Koleksiyon

Scopus İndeksli Yayınlar Koleksiyonu