The adriamycin rat/mouse model and its importance to the embryology
Küçük Resim Yok
Tarih
2012
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
Duzce University Medical School
Erişim Hakkı
info:eu-repo/semantics/closedAccess
Özet
Rat and mouse models induced by the teratogenic effect of adriamycin are reliable and easly reproducible methods of studying the embryology and molecular biology of a range of complex congenital anomalies similar to those seen in humans with VACTERL association. The mechanism by which adriamycin produces the congenital anomalies found in the VACTERL association is not yet clear. Studies with these models have focused on mainly abnormal notochord morphology, shedding more light on the important role of this structure in the developing embryo. Morover, defective Shh signaling pathway is another emphasized mechanism. This review aims to discuss adriamycin rat and mouse models and their impact on congenital anomalies similar to those seen in humans with VACTERL association, in the light of current literature data. © 2012 Düzce Medical Journal.
Açıklama
Anahtar Kelimeler
Adriamycin; Mouse; Notochord; Rat; Vacterl, Doxorubicin; Adverse Outcome; Congenital Malformation; Embryo Development; Embryotoxicity; Mouse; Nonhuman; Rat; Review; Syndrome Vater
Kaynak
Duzce Medical Journal
WoS Q Değeri
Scopus Q Değeri
Q4
Cilt
14
Sayı
2
