Evaluation of Iloprost to Prevent Vasospasm in Coronary Artery Bypass Grafts

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dc.authoridKaradag, Cetin Hakan/0000-0002-4763-986X
dc.authorwosidgur, ozcan/AAA-8847-2022
dc.authorwosidKaradag, Cetin Hakan/H-4899-2013
dc.contributor.authorEge, T.
dc.contributor.authorGur, O.
dc.contributor.authorKaradag, C. H.
dc.contributor.authorDuran, E.
dc.date.accessioned2024-06-12T11:03:40Z
dc.date.available2024-06-12T11:03:40Z
dc.date.issued2010
dc.departmentTrakya Üniversitesien_US
dc.description.abstractThis study assessed the efficacy of iloprost in relieving vasospasm in coronary artery bypass grafts. Radial artery (RA), left internal thoracic artery (LITA) and saphenous vein (SV) grafts were taken from 20 patients (13 men and seven women, mean age 63.8 years [range 48 - 74 years]) scheduled to undergo coronary artery bypass grafting. Ten 3 mm vascular rings were cut from each graft and kept under tension for at least 60 min. They were kept alive with 37 degrees C oxygenated Krebs solution. Smooth muscle contraction was achieved with phenylephrine before iloprost was administered every 2 min, starting at a concentration of 10(-9) mol/l and increasing in logarithmic increments to a concentration of 10(-5) mol/l. The vasodilation response to iloprost started in all samples at a concentration of 10(-9) mol/l and increased with each incremental increase in iloprost concentration up to 10(-5) mol/l. These data suggest that local administration of iloprost has a role in relieving graft vasospasm during harvesting and preparation for coronary artery bypass grafting.en_US
dc.identifier.doi10.1177/147323001003800521
dc.identifier.endpage1763en_US
dc.identifier.issn0300-0605
dc.identifier.issue5en_US
dc.identifier.pmid21309490en_US
dc.identifier.scopus2-s2.0-78449283506en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.startpage1759en_US
dc.identifier.urihttps://doi.org/10.1177/147323001003800521
dc.identifier.urihttps://hdl.handle.net/20.500.14551/21751
dc.identifier.volume38en_US
dc.identifier.wosWOS:000285404000021en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherField House Publishing Llpen_US
dc.relation.ispartofJournal Of International Medical Researchen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectILOPROSTen_US
dc.subjectCORONARY ARTERY BYPASSen_US
dc.subjectARTERIAL GRAFTen_US
dc.subjectVEIN GRAFTen_US
dc.subjectPulmonary-Hypertensionen_US
dc.subjectRaynauds-Phenomenonen_US
dc.subjectInhaled Iloprosten_US
dc.subjectVasodilatorsen_US
dc.subjectProstacyclinen_US
dc.subjectSurgeryen_US
dc.subjectSpasmen_US
dc.titleEvaluation of Iloprost to Prevent Vasospasm in Coronary Artery Bypass Graftsen_US
dc.typeArticleen_US

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