Evaluation of Iloprost to Prevent Vasospasm in Coronary Artery Bypass Grafts
Küçük Resim Yok
Tarih
2010
Yazarlar
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
Field House Publishing Llp
Erişim Hakkı
info:eu-repo/semantics/closedAccess
Özet
This study assessed the efficacy of iloprost in relieving vasospasm in coronary artery bypass grafts. Radial artery (RA), left internal thoracic artery (LITA) and saphenous vein (SV) grafts were taken from 20 patients (13 men and seven women, mean age 63.8 years [range 48 - 74 years]) scheduled to undergo coronary artery bypass grafting. Ten 3 mm vascular rings were cut from each graft and kept under tension for at least 60 min. They were kept alive with 37 degrees C oxygenated Krebs solution. Smooth muscle contraction was achieved with phenylephrine before iloprost was administered every 2 min, starting at a concentration of 10(-9) mol/l and increasing in logarithmic increments to a concentration of 10(-5) mol/l. The vasodilation response to iloprost started in all samples at a concentration of 10(-9) mol/l and increased with each incremental increase in iloprost concentration up to 10(-5) mol/l. These data suggest that local administration of iloprost has a role in relieving graft vasospasm during harvesting and preparation for coronary artery bypass grafting.
Açıklama
Anahtar Kelimeler
ILOPROST, CORONARY ARTERY BYPASS, ARTERIAL GRAFT, VEIN GRAFT, Pulmonary-Hypertension, Raynauds-Phenomenon, Inhaled Iloprost, Vasodilators, Prostacyclin, Surgery, Spasm
Kaynak
Journal Of International Medical Research
WoS Q Değeri
Q4
Scopus Q Değeri
Q3
Cilt
38
Sayı
5
