Histopathologic Changes in the Middle Ear Mucosa After Exposure to Pepsin and Unconjugated Bile Acid

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dc.authorid, erdogan/0000-0003-2036-6870
dc.authoridKucur, Mine/0000-0002-6579-1996
dc.authorwosidKucur, Mine/D-5015-2019
dc.authorwosiddervisoglu, sergulen/AAU-2017-2020
dc.authorwosiddevelioglu, omer n/GQB-5341-2022
dc.authorwosid, erdogan/C-4135-2015
dc.contributor.authorDevelioglu, Omer Necati
dc.contributor.authorYalcin, Enis
dc.contributor.authorBulut, Erdogan
dc.contributor.authorCelebi, Saban
dc.contributor.authorSahan, Elife
dc.contributor.authorUstundag, Nil
dc.contributor.authorDervisoglu, Sergulen
dc.date.accessioned2024-06-12T11:01:40Z
dc.date.available2024-06-12T11:01:40Z
dc.date.issued2014
dc.departmentTrakya Üniversitesien_US
dc.description.abstractObjective: An increasing number of studies indicate that pepsin and bile acid cause damage to the ear, nose, and throat structures as a result of extraesophageal reflux. The aim of this study was to evaluate and compare the damaging effect of bile acids and pepsin on the middle ear mucosa. Material and Methods: Twenty-nine healthy rats were included in this study. The animals were divided into 5 groups. A single daily dose of 40 mu mol/L chenodeoxycholic acid, 40 mu g/mL pepsin, and saline were injected separately into the right middle ear of the rats. On day 30, all rats were decapitated, and formalin-fixed, paraffin-embedded samples of the middle ear both from the control and experimental rats were prepared. A semiquantitative analysis was performed. Results: Inflammatory response was seen in all middle ear mucosa of rats except control group 1. The degree of inflammatory response was higher in the bile acid group when compared with the other groups. Epithelial metaplastic changes with varying number of goblet cells were observed in both the bile acid-and pepsin-injected groups. These metaplastic changes were also higher in the bile acid-induced group than in the pepsin-injected group. Conclusions: This is the first study on the middle ear mucosal damage of both pepsin and bile acid. Our results demonstrate that bile acids were associated with more extensive mucosal injury at pH 7 in comparison to pepsin in a rat animal model. Inflammatory response and metaplastic changes may play an important role in the etiology of middle ear pathologies.en_US
dc.identifier.doi10.1097/SCS.0000000000001041
dc.identifier.endpageE540en_US
dc.identifier.issn1049-2275
dc.identifier.issn1536-3732
dc.identifier.issue6en_US
dc.identifier.pmid25364974en_US
dc.identifier.scopus2-s2.0-84926514066en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpageE536en_US
dc.identifier.urihttps://doi.org/10.1097/SCS.0000000000001041
dc.identifier.urihttps://hdl.handle.net/20.500.14551/20984
dc.identifier.volume25en_US
dc.identifier.wosWOS:000345012000009en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherLippincott Williams & Wilkinsen_US
dc.relation.ispartofJournal Of Craniofacial Surgeryen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectExtraesophageal Refluxen_US
dc.subjectChenodeoxycholic Aciden_US
dc.subjectOtitis Mediaen_US
dc.subjectMucous Cell Metaplasiaen_US
dc.subjectInjuryen_US
dc.subjectOtitis-Mediaen_US
dc.subjectRefluxen_US
dc.subjectPathologyen_US
dc.subjectPathogenesisen_US
dc.subjectBacterialen_US
dc.subjectEffusionen_US
dc.subjectChildrenen_US
dc.subjectVirusen_US
dc.subjectModelen_US
dc.titleHistopathologic Changes in the Middle Ear Mucosa After Exposure to Pepsin and Unconjugated Bile Aciden_US
dc.typeArticleen_US

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