EFFECT OF NOMIFENSINE AND METHAMPHETAMINE ON BRAIN CATECHOLAMINES LEVELS AND OPEN-FIELD ACTIVITY OF RATS

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dc.contributor.authorALKHATIB, I
dc.contributor.authorFUJIWARA, M
dc.contributor.authorDOKMECI, I
dc.date.accessioned2024-06-12T11:09:27Z
dc.date.available2024-06-12T11:09:27Z
dc.date.issued1994
dc.departmentTrakya Üniversitesien_US
dc.description.abstractThe effects of i.p. injection of nomifensine (NOM) and methamphetamine (MA), singly and concomitantly, on ambulation and rearing in open-field test, and levels of catecholamines in nucleus accumbens (ACC) and caudate-putamen (CP) of rats were investigated. NOM at 5 and 10 mg kg(-1) increased the activity, whereas at 20 mg kg(-1) decreased it and produced in place repetitive head movements. NOM did not change catecholamines except at 20 mg kg(-1) it reduced norepinephrine in CP. MA at I and 3 mg kg(-1) increased the activity and at 3 mg kg(-1) reduced norepinephrine but elevated dopamine in CP. Concomitant injection of 20 mg kg(-1) of NOM with 3 mg kg(-1) of MA antagonized MA-induced hyperactivity and the increased levels of dopamine, whereas the in place activity and decreased level of norepinephrine in CP were still evident. NOM-hyperactivity seems to involve no significant effect on the levels of catecholamines in ACC or CP but the in place activities produced by the high dose of NOM (20 mg kg(-1)) seems to involve a decrease of norepinephrine in CP. MA-hyperactivity (at 3 mg kg(-1)) involved a decrease in norepinephrine and an increase in the level of dopamine in CP. The antagonizm of MA-hyperactivity by a high dose of NOM involved also antagonizm of MA-induced increase of dopamine in CP.en_US
dc.identifier.endpage257en_US
dc.identifier.issn0217-9687
dc.identifier.issue4en_US
dc.identifier.startpage251en_US
dc.identifier.urihttps://hdl.handle.net/20.500.14551/22802
dc.identifier.volume9en_US
dc.identifier.wosWOS:A1994QN00200003en_US
dc.identifier.wosqualityN/Aen_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.language.isoenen_US
dc.publisherSingapore Univ Press Univ Singaporeen_US
dc.relation.ispartofAsia Pacific Journal Of Pharmacologyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectNUCLEUS ACCUMBENSen_US
dc.subjectCAUDATE-PUTAMENen_US
dc.subjectNOMIFENSINEen_US
dc.subjectMETHAMPHETAMINEen_US
dc.subjectCATECHOLAMINESen_US
dc.subjectHYPERACTIVITYen_US
dc.titleEFFECT OF NOMIFENSINE AND METHAMPHETAMINE ON BRAIN CATECHOLAMINES LEVELS AND OPEN-FIELD ACTIVITY OF RATSen_US
dc.typeArticleen_US

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