EFFECT OF NOMIFENSINE AND METHAMPHETAMINE ON BRAIN CATECHOLAMINES LEVELS AND OPEN-FIELD ACTIVITY OF RATS
Küçük Resim Yok
Tarih
1994
Yazarlar
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
Singapore Univ Press Univ Singapore
Erişim Hakkı
info:eu-repo/semantics/closedAccess
Özet
The effects of i.p. injection of nomifensine (NOM) and methamphetamine (MA), singly and concomitantly, on ambulation and rearing in open-field test, and levels of catecholamines in nucleus accumbens (ACC) and caudate-putamen (CP) of rats were investigated. NOM at 5 and 10 mg kg(-1) increased the activity, whereas at 20 mg kg(-1) decreased it and produced in place repetitive head movements. NOM did not change catecholamines except at 20 mg kg(-1) it reduced norepinephrine in CP. MA at I and 3 mg kg(-1) increased the activity and at 3 mg kg(-1) reduced norepinephrine but elevated dopamine in CP. Concomitant injection of 20 mg kg(-1) of NOM with 3 mg kg(-1) of MA antagonized MA-induced hyperactivity and the increased levels of dopamine, whereas the in place activity and decreased level of norepinephrine in CP were still evident. NOM-hyperactivity seems to involve no significant effect on the levels of catecholamines in ACC or CP but the in place activities produced by the high dose of NOM (20 mg kg(-1)) seems to involve a decrease of norepinephrine in CP. MA-hyperactivity (at 3 mg kg(-1)) involved a decrease in norepinephrine and an increase in the level of dopamine in CP. The antagonizm of MA-hyperactivity by a high dose of NOM involved also antagonizm of MA-induced increase of dopamine in CP.
Açıklama
Anahtar Kelimeler
NUCLEUS ACCUMBENS, CAUDATE-PUTAMEN, NOMIFENSINE, METHAMPHETAMINE, CATECHOLAMINES, HYPERACTIVITY
Kaynak
Asia Pacific Journal Of Pharmacology
WoS Q Değeri
N/A
Scopus Q Değeri
Cilt
9
Sayı
4
