One-pot gold(i)-catalyzed synthesis of 2-pyridonyl alcohols

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dc.authoridKARATAVUK, Ali Osman/0000-0001-6616-4065
dc.authorwosidKARATAVUK, Ali Osman/AAE-8175-2019
dc.contributor.authorKaratavuk, Ali Osman
dc.date.accessioned2024-06-12T11:18:58Z
dc.date.available2024-06-12T11:18:58Z
dc.date.issued2021
dc.departmentTrakya Üniversitesien_US
dc.description.abstractA highly efficient method for the synthesis of 2-pyridonyl alcohols via gold(i) catalyst was developed. The effect of methanesulfonic acid on the reaction progression with the gold catalyst was determined. The proposed mechanism involves intramolecular cyclization product formation derived from 5-exo-dig and 6-exo-dig addition of the nitrogen for 2-propargyloxypyridine and 2-(but-3-yn-1-yloxy)pyridine, respectively. The pyridinium salt formed by the gold(i) catalyst and methanesulfonic acid undergoes a rearrangement reaction in a weakly basic medium (5% aq. Na2CO3) to form N-alkenyl pyridonyl alcohols. N-alkenyl pyridonyl alcohols can be obtained in moderate to excellent yields using this method.en_US
dc.description.sponsorshipTrakya University Scientific Research Projects Unit [TUBAP 2018/368, TUBAP 2020/32]en_US
dc.description.sponsorshipWe thank Trakya University Scientific Research Projects Unit for its support through project number TUBAP 2018/368 and TUBAP 2020/32.en_US
dc.identifier.doi10.1039/d1ob01950c
dc.identifier.endpage10621en_US
dc.identifier.issn1477-0520
dc.identifier.issn1477-0539
dc.identifier.issue48en_US
dc.identifier.pmid34874032en_US
dc.identifier.scopus2-s2.0-85121642632en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.startpage10617en_US
dc.identifier.urihttps://doi.org/10.1039/d1ob01950c
dc.identifier.urihttps://hdl.handle.net/20.500.14551/25025
dc.identifier.volume19en_US
dc.identifier.wosWOS:000727419200001en_US
dc.identifier.wosqualityQ1en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherRoyal Soc Chemistryen_US
dc.relation.ispartofOrganic & Biomolecular Chemistryen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectGolden_US
dc.subjectRearrangementen_US
dc.subjectAlkyneen_US
dc.subjectEfficienten_US
dc.subjectPyridonesen_US
dc.titleOne-pot gold(i)-catalyzed synthesis of 2-pyridonyl alcoholsen_US
dc.typeArticleen_US

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