One-pot gold(i)-catalyzed synthesis of 2-pyridonyl alcohols
Küçük Resim Yok
Tarih
2021
Yazarlar
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
Royal Soc Chemistry
Erişim Hakkı
info:eu-repo/semantics/closedAccess
Özet
A highly efficient method for the synthesis of 2-pyridonyl alcohols via gold(i) catalyst was developed. The effect of methanesulfonic acid on the reaction progression with the gold catalyst was determined. The proposed mechanism involves intramolecular cyclization product formation derived from 5-exo-dig and 6-exo-dig addition of the nitrogen for 2-propargyloxypyridine and 2-(but-3-yn-1-yloxy)pyridine, respectively. The pyridinium salt formed by the gold(i) catalyst and methanesulfonic acid undergoes a rearrangement reaction in a weakly basic medium (5% aq. Na2CO3) to form N-alkenyl pyridonyl alcohols. N-alkenyl pyridonyl alcohols can be obtained in moderate to excellent yields using this method.
Açıklama
Anahtar Kelimeler
Gold, Rearrangement, Alkyne, Efficient, Pyridones
Kaynak
Organic & Biomolecular Chemistry
WoS Q Değeri
Q1
Scopus Q Değeri
Q1
Cilt
19
Sayı
48
