The Role of Alpha Atrial Natriuretic Hormone in Pneumonectomy: An Experimental Study

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dc.contributor.authorAkkuş, Murat
dc.contributor.authorYörük, Yener
dc.date.accessioned2024-06-12T09:23:15Z
dc.date.available2024-06-12T09:23:15Z
dc.date.issued2019
dc.departmentTrakya Üniversitesien_US
dc.description.abstractObjective: The alpha atrial natriuretic hormone (?-ANH) is released in response to atrialdistension and excessive fluid volume in the body. The aim of the present study was to evaluate ?-ANH levels before and after pneumonectomy and to investigate the effects of normaland increased volume of crystalloid–colloid fluids on ?-ANH following pneumonectomy ina rabbit model.Methods: A total of 20 New Zealand rabbits were used in the study. The mean weightof the rabbits was 1.831 g. The subjects were divided into four groups with five in eachgroup. The first group was given 3 mL/kg/h of crystalloid; the second group was given 10mL/kg/h of crystalloid; the third group was given 3 mL/kg/h of colloid; the fourth group wasgiven 10 mL/kg/h of colloid. Blood samples were preoperatively collected from the jugularvein. Posterolateral thoracotomy was applied to all subjects. The hilus was tied and cut enbloc with 2/0 silk, and pneumonectomy was performed. All groups received infusion for 3h. Following infusion, blood samples from the contralateral jugular vein were collected atpostoperative 3 h. Pre- and postoperative ?-ANH levels were compared.Results: There was no significant difference in the mean weight of the groups (?2=1.417,p=0.478). There was no significant difference in the pre- and postoperative ?-ANH levelsamong all groups (Z=0.674, p=0.5 in the first; Z=0.405, p=0.686 in the second; Z=1.753,p=0.08 in the third; Z=0.944, p=0.345 in the fourth).Conclusion: Our study results suggest that pneumonectomy alone appears not to changethe ?-ANH levels, and hypoxia, increased atrial pressure, and some neurohormonal factorsmay enhance ?-ANH release.en_US
dc.identifier.doi10.14744/scie.2019.07769
dc.identifier.endpage106en_US
dc.identifier.issn2587-0998
dc.identifier.issn2587-1404
dc.identifier.issue2en_US
dc.identifier.startpage101en_US
dc.identifier.trdizinid345702en_US]
dc.identifier.urihttps://doi.org/10.14744/scie.2019.07769
dc.identifier.urihttps://search.trdizin.gov.tr/yayin/detay/345702
dc.identifier.urihttps://hdl.handle.net/20.500.14551/12557
dc.identifier.volume30en_US
dc.indekslendigikaynakTR-Dizinen_US
dc.language.isoenen_US
dc.relation.ispartofSouthern Clinics of Istanbul Eurasiaen_US
dc.relation.publicationcategoryMakale - Ulusal Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.titleThe Role of Alpha Atrial Natriuretic Hormone in Pneumonectomy: An Experimental Studyen_US
dc.typeArticleen_US

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